腺胃扩张病的发病机制。
The pathogenesis of proventricular dilatation disease.
作者信息
Tizard Ian, Shivaprasad H L, Guo Jianhua, Hameed Samer, Ball Judith, Payne Susan
机构信息
Department of Veterinary Pathobiology and the Schubot Exotic Bird Health Center,Texas A&M University,College Station,TX 77843,USA.
University of California Animal Health and Food Safety Laboratory System-Tulare, University of California,Davis,Tulare, CA,USA.
出版信息
Anim Health Res Rev. 2016 Dec;17(2):110-126. doi: 10.1017/S1466252316000189.
Bornaviruses cause neurologic diseases in several species of birds, especially parrots, waterfowl and finches. The characteristic lesions observed in these birds include encephalitis and gross dilatation of the anterior stomach - the proventriculus. The disease is thus known as proventricular dilatation disease (PDD). PDD is characterized by extreme proventricular dilatation, blockage of the passage of digesta and consequent death by starvation. There are few clinical resemblances between this and the bornaviral encephalitides observed in mammals. Nevertheless, there are common virus-induced pathogenic pathways shared across this disease spectrum that are explored in this review. Additionally, a review of the literature relating to gastroparesis in humans and the control of gastric mobility in mammals and birds points to several plausible mechanisms by which bornaviral infection may result in extreme proventricular dilatation.
博尔纳病毒可在多种鸟类中引发神经疾病，尤其是鹦鹉、水禽和雀类。在这些鸟类身上观察到的特征性病变包括脑炎和前胃（腺胃）的明显扩张。因此，这种疾病被称为腺胃扩张病（PDD）。PDD的特征是腺胃极度扩张、消化物通过受阻，进而因饥饿而死亡。这与在哺乳动物中观察到的博尔纳病毒性脑炎几乎没有临床相似之处。然而，本综述探讨了在这一疾病谱中共同存在的病毒诱导致病途径。此外，对人类胃轻瘫以及哺乳动物和鸟类胃动力控制相关文献的综述指出了几种博尔纳病毒感染可能导致腺胃极度扩张的合理机制。
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