Hoppes Sharman, Gray Patricia L, Payne Susan, Shivaprasad H L, Tizard Ian
Small Animal Clinical Sciences, Texas A&M University, 4474 TAMU, College Station, TX 77843, USA.
Vet Clin North Am Exot Anim Pract. 2010 Sep;13(3):495-508. doi: 10.1016/j.cvex.2010.05.014.
Proventricular dilatation disease (PDD) is a common infectious neurologic disease of birds comprising a dilatation of the proventriculus by ingested food as a result of defects in intestinal motility, which affects more than 50 species of psittacines, and is also known as Macaw wasting disease, neuropathic ganglioneuritis, or lymphoplasmacytic ganglioneuritis. Definitive diagnosis of PDD has been problematic due to the inconsistent distribution of lesions. Since its discovery, avian bornavirus (ABV) has been successfully cultured from the brains of psittacines diagnosed with PDD, providing a source of antigen for serologic assays and nucleic acid for molecular assays. This article provides evidence that ABV is the etiologic agent of PDD. Recent findings on the transmission, epidemiology, pathogenesis, diagnosis, and control of ABV infection and PDD are also reviewed.
前胃扩张病（PDD）是鸟类常见的传染性神经疾病，由于肠道蠕动缺陷，摄入的食物导致前胃扩张，影响超过50种鹦鹉，也被称为金刚鹦鹉消瘦病、神经性神经节神经炎或淋巴浆细胞性神经节神经炎。由于病变分布不一致，PDD的确诊一直存在问题。自发现以来，禽博尔纳病毒（ABV）已成功从诊断为PDD的鹦鹉大脑中培养出来，为血清学检测提供了抗原来源，为分子检测提供了核酸。本文提供了ABV是PDD病原体的证据。还综述了ABV感染和PDD的传播、流行病学、发病机制、诊断和控制方面的最新研究结果。
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