Leal de Araújo Jeann, Rech Raquel Rubia
Department of Veterinary Sciences, Center for Agricultural Sciences, Federal University of Paraíba, Areia 58397000, Paraiba, Brazil.
Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843-4467, USA.
Animals (Basel). 2021 Dec 14;11(12):3558. doi: 10.3390/ani11123558.
Proventricular dilatation disease (PDD) is a life-threatening neurological disease caused by parrot bornaviruses (PaBVs) that affects several species worldwide. PDD can be clinically manifested as either a central nervous system condition or a gastrointestinal condition if the nerves and ganglia of the gastrointestinal tract are compromised. We intend to provide a concise review for veterinary clinicians and diagnosticians with focus on the main tools available for PDD diagnosis, including gross and histopathology, immunohistochemistry, molecular techniques and serology. We suggest that a combination of different strategies can increase the success of diagnostic outcomes, as tools such as reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) can be implemented for identification of bornaviral infections in live patients, and gross pathology, histopathology, immunohistochemistry and RT-PCR can provide reliable results for postmortem diagnosis of PDD.
嗉囊扩张病（PDD）是一种由鹦鹉博尔纳病毒（PaBVs）引起的危及生命的神经疾病，影响着全球多个物种。如果胃肠道的神经和神经节受到损害，PDD在临床上可表现为中枢神经系统疾病或胃肠道疾病。我们旨在为兽医临床医生和诊断人员提供一篇简明综述，重点介绍可用于PDD诊断的主要工具，包括大体病理学和组织病理学、免疫组织化学、分子技术和血清学。我们建议，不同策略的组合可以提高诊断结果的成功率，因为诸如逆转录聚合酶链反应（RT-PCR）和酶联免疫吸附测定（ELISA）等工具可用于识别活体患者的博尔纳病毒感染，而大体病理学、组织病理学、免疫组织化学和RT-PCR可为PDD的死后诊断提供可靠结果。
