Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, 17493 Greifswald, Insel Riems, Germany.
Viruses. 2022 Jul 11;14(7):1513. doi: 10.3390/v14071513.
Avian bornaviruses constitute a genetically diverse group of at least 15 viruses belonging to the genus within the family . After the discovery of the first avian bornaviruses in diseased psittacines in 2008, further viruses have been detected in passerines and aquatic birds. Parrot bornaviruses (PaBVs) possess the highest veterinary relevance amongst the avian bornaviruses as the causative agents of proventricular dilatation disease (PDD). PDD is a chronic and often fatal disease that may engulf a broad range of clinical presentations, typically including neurologic signs as well as impaired gastrointestinal motility, leading to proventricular dilatation. It occurs worldwide in captive psittacine populations and threatens private bird collections, zoological gardens and rehabilitation projects of endangered species. In contrast, only little is known about the pathogenic roles of passerine and waterbird bornaviruses. This comprehensive review summarizes the current knowledge on avian bornavirus infections, including their taxonomy, pathogenesis of associated diseases, epidemiology, diagnostic strategies and recent developments on prophylactic and therapeutic countermeasures.
禽源博尔纳病毒属于呼肠孤病毒科正呼肠孤病毒属，是一个遗传多样性的病毒群，至少包含 15 种病毒。2008 年在患病鹦鹉中首次发现禽源博尔纳病毒后，又在雀形目鸟类和水禽中检测到了其他禽源博尔纳病毒。鹦鹉源博尔纳病毒（PaBVs）在禽源博尔纳病毒中具有最高的兽医相关性，是导致前胃扩张病（PDD）的病原体。PDD 是一种慢性且常致命的疾病，可能出现多种临床表现，通常包括神经症状以及胃肠道蠕动障碍，导致前胃扩张。该病在世界各地的圈养鹦鹉种群中流行，并威胁着私人鸟类收藏、动物园和濒危物种的康复项目。相比之下，人们对雀形目鸟类和水禽源博尔纳病毒的致病作用知之甚少。本综述全面总结了禽源博尔纳病毒感染的相关知识，包括其分类学、相关疾病的发病机制、流行病学、诊断策略以及预防性和治疗性对策的最新进展。
