Prokopenko N P, Tigranian R A, Muratova G L, Plokhoĭ V I, Khavinson V Kh
Vopr Med Khim. 1989 Jul-Aug;35(4):79-81.
Acid extract of bovine epiphyses was separated by means of gel filtration on Sephadex G-50 into two fractions: high and low molecular preparations. Estimation of biological activity of the acid extract and its polypeptide fractions, which was carried out using the procedure of antigonadotropic effect on preadolescent rat females, showed that the antigonadotropic effect was distinctly higher in the preparation free of high molecular substances.
牛骨骺的酸提取物通过在葡聚糖凝胶G - 50上进行凝胶过滤，分离为两个部分：高分子制剂和低分子制剂。使用对青春期前雌性大鼠的抗促性腺作用程序，对酸提取物及其多肽部分的生物活性进行评估，结果表明，在不含高分子物质的制剂中，抗促性腺作用明显更高。
