Walsh Edward E
Infectious Diseases Division, Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine, 1425 Portland Avenue, Rochester, NY 14621, USA.
Clin Chest Med. 2017 Mar;38(1):29-36. doi: 10.1016/j.ccm.2016.11.010. Epub 2016 Dec 27.
Respiratory syncytial virus (RSV) is the single most important cause of severe respiratory infection in very young infants. It has also been recently recognized as a significant cause of severe illness in elderly adults, those with underlying cardiopulmonary disease, and the immunocompromised. RSV is suspected of playing a major role in the development of asthma. Prophylaxis in high-risk infants using a monoclonal antibody is the only effective specific therapy available but recent breakthroughs in vaccine design and antiviral drugs offer the promise of effective prophylactic and therapeutic agents against RSV.
呼吸道合胞病毒（RSV）是引起极幼龄婴儿严重呼吸道感染的唯一最重要病因。最近它也被认为是导致老年人、患有基础心肺疾病者以及免疫功能低下者患重病的一个重要病因。RSV被怀疑在哮喘的发生发展中起主要作用。使用单克隆抗体对高危婴儿进行预防是目前唯一有效的特异性治疗方法，但疫苗设计和抗病毒药物方面的最新突破为开发有效的RSV预防和治疗药物带来了希望。
