Fusch Gerhard, Kwan Celia, Kotrri Gynter, Fusch Christoph
Division of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada.
Division of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada; Department of Pediatrics, Paracelsus Medical School, General Hospital of Nuremberg, Breslauer Straße 201, Nuremberg 90471, Germany.
Clin Perinatol. 2017 Mar;44(1):209-267. doi: 10.1016/j.clp.2016.11.001. Epub 2016 Dec 29.
Human milk analyzers can measure macronutrient content in native breast milk to tailor adequate supplementation with fortifiers. This article reviews all studies using milk analyzers, including (i) evaluation of devices, (ii) the impact of different conditions on the macronutrient analysis of human milk, and (iii) clinical trials to improve growth. Results lack consistency, potentially due to systematic errors in the validation of the device, or pre-analytical sample preparation errors like homogenization. It is crucial to introduce good laboratory and clinical practice when using these devices; otherwise a non-validated clinical usage can severely affect growth outcomes of infants.
母乳分析仪可以测量天然母乳中的宏量营养素含量，以便定制适当的强化剂补充方案。本文回顾了所有使用母乳分析仪的研究，包括：（i）设备评估；（ii）不同条件对母乳宏量营养素分析的影响；以及（iii）改善生长情况的临床试验。研究结果缺乏一致性，这可能是由于设备验证中的系统误差，或诸如均质化等分析前样本制备误差所致。使用这些设备时引入良好的实验室和临床规范至关重要；否则，未经验证的临床应用可能会严重影响婴儿的生长结果。
