Grosskopf Hyolanda M, Schwertz Claiton I, Machado Gustavo, Bottari Nathieli B, da Silva Ester S, Gabriel Mateus E, Lucca Neuber J, Alves Mariana S, Schetinger Maria Rosa C, Morsch Vera M, Mendes Ricardo E, da Silva Aleksandro S
Departamento of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC, Brazil.
Veterinary School, Instituto Federal Catarinense (IFC), Concórdia, SC, Brazil.
Res Vet Sci. 2017 Feb;110:79-84. doi: 10.1016/j.rvsc.2016.10.016. Epub 2016 Oct 29.
The enzyme adenosine deaminase (ADA) is critical for modulating the immune system, and in the presence of zinc, its activity is catalyzed. The aim of this study was to evaluate the ADA activity in pancreas of cattle naturally infected by Eurytrema coelomaticum in relation to the results of zinc levels, pathological findings and parasite load. For this study 51 slaughtered cattle were used. The animals were divided into two groups: Group A consisting of animals naturally infected by E. coelomaticum (n=33) and Group B of uninfected animals (n=18). Blood and pancreas were collected of each animal for analysis of zinc and ADA, respectively. Infected cattle showed a reduction on seric levels of zinc, and decreased ADA activity in the pancreas (P>0.05). A positive correlation between zinc levels and ADA activity was observed. Thus, high parasite load and severity of histopathologic lesions affect the ADA activity in pancreas, as well as the zinc levels in serum of infected animals (negative correlation between these variables). Therefore, we can conclude that cattle infected by E. coelomaticum have low ADA activity in pancreas, which can be directly related to zinc reduction, responsible for ADA activation and catalyzes.
腺苷脱氨酶（ADA）对于调节免疫系统至关重要，并且在锌存在的情况下，其活性会被催化。本研究的目的是评估自然感染腔阔盘吸虫的牛胰腺中的ADA活性，以及锌水平、病理结果和寄生虫负荷的结果。本研究使用了51头屠宰牛。动物被分为两组：A组由自然感染腔阔盘吸虫的动物组成（n = 33），B组为未感染动物（n = 18）。分别采集每只动物的血液和胰腺用于分析锌和ADA。感染牛的血清锌水平降低，胰腺中的ADA活性降低（P>0.05）。观察到锌水平与ADA活性之间呈正相关。因此，高寄生虫负荷和组织病理学病变的严重程度会影响感染动物胰腺中的ADA活性以及血清中的锌水平（这些变量之间呈负相关）。因此，我们可以得出结论，感染腔阔盘吸虫的牛胰腺中的ADA活性较低，这可能与锌减少直接相关，锌负责ADA的激活和催化。
