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北极格陵兰岛接种疫苗后血清呈阳性个体中的亚临床麻疹感染

Subclinical measles infection in vaccinated seropositive individuals in arctic Greenland.

作者信息

Pedersen I R, Mordhorst C H, Glikmann G, von Magnus H

机构信息

Institute of Medical Microbiology, University of Copenhagen, Denmark.

出版信息

Vaccine. 1989 Aug;7(4):345-8. doi: 10.1016/0264-410x(89)90199-0.

Abstract

Measles vaccination was performed in the arctic district of Scoresbysund, Greenland in 1968, which had never been exposed to natural measles. More than 90% of the total population was vaccinated and a 94-100% seroconversion was obtained. During a serological survey to examine the immunity status of the vaccinees, it was discovered that a temporary increase in measles antibodies took place in the majority of the population 2-4 years after the vaccination. This was not accompanied by clinically observed measles. Most likely, it was due to an inapparent measles infection in a population considered highly immune after vaccination.

摘要

1968年,在格陵兰斯科斯比松的北极地区进行了麻疹疫苗接种,该地区从未接触过自然麻疹。超过90%的总人口接种了疫苗,血清转化率达到94%-100%。在一项检查疫苗接种者免疫状态的血清学调查中发现,大多数人在接种疫苗2-4年后麻疹抗体出现暂时增加。这并未伴随临床上观察到的麻疹。最有可能的原因是,在被认为接种疫苗后具有高度免疫力的人群中发生了隐性麻疹感染。

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