Rustagi Tarun, Chhoda Ankit
Division of Gastroenterology and Hepatology, University of New Mexico, MSC10 5550, 1 University of New Mexico, Albuquerque, NM, 87131, USA.
Department of Internal Medicine, Waterbury Hospital, Waterbury, CT, USA.
Dig Dis Sci. 2017 Apr;62(4):843-850. doi: 10.1007/s10620-017-4452-y. Epub 2017 Feb 3.
Radiofrequency ablation (RFA) is a well-established technique to ablate dysplastic and neoplastic tissue via local thermal coagulative necrosis. Despite the widespread use in management of several cancers, the application of RFA in pancreas has been limited due to the increased risks of complications from the increased sensitivity of pancreatic tissue to thermal injury and proximity to vascular and biliary structures. RFA has been successfully used during laparotomy for locally advanced pancreatic carcinoma but requires an invasive approach. Endoscopic ultrasound-guided RFA offers the best combination of excellent visualization, real-time imaging guidance, and precise localization with minimal invasiveness. Several animal and human studies have demonstrated the technical feasibility and safety of endoscopic RFA in the pancreas. This article provides a comprehensive review of endoscopic RFA in the management of pancreatic lesions.
射频消融术（RFA）是一种成熟的技术，可通过局部热凝性坏死来消融发育异常和肿瘤组织。尽管RFA在多种癌症的治疗中广泛应用，但由于胰腺组织对热损伤的敏感性增加以及与血管和胆道结构相邻，导致并发症风险增加，RFA在胰腺疾病中的应用受到限制。RFA已成功用于剖腹手术治疗局部晚期胰腺癌，但需要侵入性操作。内镜超声引导下的RFA提供了极佳的可视化、实时成像引导以及精确的定位，同时侵入性最小，是最佳的组合方式。多项动物和人体研究已证明内镜RFA在胰腺疾病治疗中的技术可行性和安全性。本文对内镜RFA在胰腺病变管理中的应用进行了全面综述。
