Eberle R, Black Darla H
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.
Arch Virol. 2017 May;162(5):1423-1425. doi: 10.1007/s00705-017-3249-9. Epub 2017 Feb 3.
Here, we report the genome sequence of a spider monkey alphaherpesvirus (ateline alphaherpesvirus 1, HVA1) and compare it with that of other primate alphaherpesviruses. The HVA1 genome is 147,346 bp long and contains 67 predicted ORFs. The genetic layout of the HVA1 genome is similar to that of the squirrel monkey alphaherpesvirus (saimirine alphaherpesvirus 1, HVS1) in that it lacks inverted repeat regions flanking the unique long region and homologues of the UL43, UL49.5, US8.5 and US10-12 genes. Unlike HVS1, HVA1 also lacks a homologue of the RL1 (γ34.5) gene and a replication origin near the end of the genome. Consistent with previous phylogenetic analyses, all predicted proteins of HVA1 are most closely related to those of HVS1.
在此，我们报告了一种蜘蛛猴甲型疱疹病毒（蛛猴甲型疱疹病毒1型，HVA1）的基因组序列，并将其与其他灵长类甲型疱疹病毒的基因组序列进行比较。HVA1基因组长度为147,346 bp，包含67个预测的开放阅读框。HVA1基因组的基因布局与松鼠猴甲型疱疹病毒（松鼠猴甲型疱疹病毒1型，HVS1）相似，即其独特长区域两侧缺乏反向重复区域，且缺少UL43、UL49.5、US8.5和US10 - 12基因的同源物。与HVS1不同的是，HVA1还缺少RL1（γ34.5）基因的同源物以及基因组末端附近的一个复制起点。与先前的系统发育分析一致，HVA1的所有预测蛋白与HVS1的预测蛋白关系最为密切。
