Ohsawa Kazutaka, Black Darla, Ohsawa Makiko, Eberle R
Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, Nagasaki, Japan.
Arch Virol. 2014 Oct;159(10):2819-21. doi: 10.1007/s00705-014-2130-3. Epub 2014 Jun 6.
The only genome sequence for monkey B virus (BV; species Macacine herpesvirus 1) is that of an attenuated vaccine strain originally isolated from a rhesus monkey (BVrh). Here we report the genome sequence of a virulent BV strain isolated from a cynomolgus macaque (BVcy). The overall genome organization is the same, although sequence differences exist. The greatest sequence divergence is located in non-coding areas of the long and short repeat regions. Like BVrh, BVcy has duplicated Ori elements and lacks an ORF corresponding to the γ34.5 gene of herpes simplex virus. Nine of ten miRNAs and the majority of ORFs are conserved between BVrh and BVcy. The most divergent genes are several membrane-associated proteins and those encoding immediate early proteins.
猴B病毒（BV；猕猴疱疹病毒1型）的唯一基因组序列是最初从恒河猴分离出的减毒疫苗株（BVrh）的序列。在此，我们报告了从食蟹猕猴分离出的强毒BV株（BVcy）的基因组序列。尽管存在序列差异，但整体基因组结构相同。最大的序列差异位于长重复区域和短重复区域的非编码区。与BVrh一样，BVcy有重复的Ori元件，并且缺乏与单纯疱疹病毒γ34.5基因相对应的开放阅读框（ORF）。在BVrh和BVcy之间，十分之九的微小RNA（miRNA）和大多数开放阅读框是保守的。差异最大的基因是几种膜相关蛋白和那些编码立即早期蛋白的基因。
