Post-Graduate Program in Psychiatry and Behavioral Sciences, Federal University at Rio Grande do Sul, Brazil; PTSD Outpatient program (NET-Trauma), Hospital de Clínicas de Porto Alegre, Brazil.
Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Psychiatry Res. 2017 Apr;250:136-140. doi: 10.1016/j.psychres.2017.01.072. Epub 2017 Jan 25.
The exposition to traumatic events related to urban violence is epidemic in Brazil, with rate of 80% in the general population, and is becoming a major cause of post-traumatic stress disorder (PTSD). The objective of the study was to compare serum levels of pro-inflammatory interleukin-6 (IL-6) and anti-inflammatory interleukin-10 (IL-10) in PTSD and resilient individuals. We hypothesized that resilient individuals present an attenuated pro-inflammatory and enhanced anti-inflammatory state. We conducted a case-control study comparing 30 resilient individuals and 30 PTSD patients exposed to traumatic events related to urban violence. The groups were evaluated using Self-Report Questionnaire (SRQ-20), Mini-International Neuropsychiatric Interview (MINI) and the Davidson Trauma Scale. For all individuals, blood samples were collected to determine IL-6, IL-10 and cortisol serum levels. All samples were frozen at -80°C until the assay and were analyzed with the same immunoassay kit and in duplicates. The resilient group presented higher IL-10 levels than PTSD patients [mean (CI95%); 1.03 (0.52-2.08) pg/mL vs. 0.29 (0.20-0.43) pg/mL; P=0.002]. There were no differences in terms of IL-6 or cortisol levels. The results provided evidence for increased levels of IL-10 in resilient individuals when compared to PTSD patients, probably conferring them a better anti-inflammatory response after exposition.
创伤暴露于与城市暴力相关的事件在巴西很普遍，发生率达 80%，这已成为创伤后应激障碍（PTSD）的主要原因。本研究旨在比较 PTSD 和适应良好个体的促炎细胞因子白细胞介素-6（IL-6）和抗炎细胞因子白细胞介素-10（IL-10）的血清水平。我们假设适应良好的个体表现出抗炎状态减弱和抗炎状态增强。我们进行了一项病例对照研究，比较了 30 名适应良好的个体和 30 名创伤暴露于与城市暴力相关的事件的 PTSD 患者。使用自我报告问卷（SRQ-20）、迷你国际神经精神访谈（MINI）和戴维森创伤量表对两组进行评估。对所有个体采集血样，以确定 IL-6、IL-10 和皮质醇的血清水平。所有样本在-80°C 下冷冻，直至进行测定，并使用相同的免疫测定试剂盒和重复分析。适应良好组的 IL-10 水平高于 PTSD 患者[平均值（95%CI）；1.03（0.52-2.08）pg/mL 比 0.29（0.20-0.43）pg/mL；P=0.002]。IL-6 或皮质醇水平没有差异。与 PTSD 患者相比，适应良好个体的 IL-10 水平升高，这可能使他们在暴露后具有更好的抗炎反应。
