Sánchez Fernández Iván, Peters Jurriaan M, Akhondi-Asl Alireza, Klehm Jacquelyn, Warfield Simon K, Loddenkemper Tobias
Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, Spain.
Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Epilepsy Res. 2017 Feb;130:74-80. doi: 10.1016/j.eplepsyres.2017.01.010. Epub 2017 Jan 27.
To test whether patients with Electrical Status Epilepticus in Sleep (ESES) and normal neuroimaging have a smaller thalamic volume than expected for age and for total brain volume.
Case-control study comparing three groups of subjects of 4-14 years of age and normal magnetic resonance imaging: 1) ESES patients, 2) patients with refractory epilepsy control group, and 3) healthy controls. Thalamic and total brain volumes were calculated using an algorithm for automatic segmentation and parcellation of magnetic resonance imaging.
Eighteen ESES patients, 29 refractory epilepsy controls and 51 healthy controls were included. The median (p25-p75) age was 8.8 (7.5-10.3) years for ESES patients, 11 (7-12) years for healthy controls, and 9 (6.3-11.2) years for refractory epilepsy controls. After correcting for total brain volume and age, the left thalamus was not statistically significantly smaller in ESES patients than in healthy controls (p=0.077), in ESES patients than in refractory epilepsy controls (p=0.056); but the right thalamus was smaller in ESES patients than in healthy controls (p=0.044), and in ESES patients than in refractory epilepsy controls (p=0.033).
Patients with ESES and normal magnetic resonance imaging have smaller relative thalamic volume controlling for age and total brain volume.
检验睡眠中癫痫性电持续状态（ESES）且神经影像学正常的患者丘脑体积是否小于其年龄及全脑体积预期值。
病例对照研究，比较三组4至14岁且磁共振成像正常的受试者：1）ESES患者；2）难治性癫痫对照组患者；3）健康对照者。使用磁共振成像自动分割和分区算法计算丘脑及全脑体积。
纳入18例ESES患者、29例难治性癫痫对照者和51例健康对照者。ESES患者的年龄中位数（第25百分位数-第75百分位数）为8.8（7.5-10.3）岁，健康对照者为11（7-12）岁，难治性癫痫对照者为9（6.3-11.2）岁。在校正全脑体积和年龄后，ESES患者的左侧丘脑与健康对照者相比无统计学显著减小（p=0.077），与难治性癫痫对照者相比也无统计学显著减小（p=0.056）；但ESES患者的右侧丘脑小于健康对照者（p=0.044），且小于难治性癫痫对照者（p=0.033）。
ESES且磁共振成像正常的患者在控制年龄和全脑体积后丘脑相对体积较小。
