Inserm U 1035, 33076 Bordeaux, France; Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France.
Inserm U 1035, 33076 Bordeaux, France; Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France; Centre de Référence pour les Maladies Rares de la Peau, CHU de Bordeaux, France.
Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):712-722. doi: 10.1016/j.bbabio.2017.01.013. Epub 2017 Feb 1.
Skin cancers are the most common cancers worldwide. The incidence of common skin cancers, including basal cell carcinomas (BCCs), squamous cell carcinomas (SCCs) and melanomas, continues to rise by 5 to 7% per year, mainly due to ultraviolet (UV) exposure and partly because of aging. This suggests an urgent necessity to improve the level of prevention and protection for skin cancers as well as developing new prognostic and diagnostic markers of skin cancers. Moreover, despite innovative therapies especially in the fields of melanoma and carcinomas, new therapeutic options are needed to bypass resistance to targeted therapies or treatment's side effects. Since reprogramming of cellular metabolism is now considered as a hallmark of cancer, some of the recent findings on the role of energy metabolism in skin cancer initiation and progression as well as its effect on the response to targeted therapies are discussed in this review. This article is part of a Special Issue entitled Mitochondria in cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.
皮肤癌是全球最常见的癌症。包括基底细胞癌（BCC）、鳞状细胞癌（SCC）和黑色素瘤在内的常见皮肤癌的发病率每年持续上升 5%至 7%，这主要归因于紫外线（UV）暴露，部分原因是由于衰老。这表明迫切需要提高皮肤癌的预防和保护水平，并开发皮肤癌的新预后和诊断标志物。此外，尽管在黑色素瘤和癌领域有创新疗法，但仍需要新的治疗选择来克服对靶向治疗的耐药性或治疗的副作用。由于细胞代谢的重编程现在被认为是癌症的一个标志，因此，本文讨论了能量代谢在皮肤癌发生和发展中的作用及其对靶向治疗反应的影响的最新发现。本文是由 Giuseppe Gasparre、Rodrigue Rossignol 和 Pierre Sonveaux 编辑的题为“癌症中的线粒体”的特刊的一部分。
