维生素 E 补充对一些妊娠健康指标的影响：一项随机临床试验。
Effects of vitamin E supplementation on some pregnancy health indices: a randomized clinical trial.
机构信息
Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Int J Gen Med. 2011;4:461-4. doi: 10.2147/IJGM.S20107. Epub 2011 Jun 15.
Abstract
OBJECTIVE
Available evidence about the role of supplementary vitamin E in normal pregnancy is inadequate. This study assessed the potential benefit of vitamin E supplementation on some pregnancy health indices.
METHODS
A 1:2 weighted simple randomization technique was used to allocate 104 eligible pregnant women to receive vitamin E and 168 women (control) not to receive the drug. Treated women received capsules containing 400 IU vitamin E from week 14 of gestation to the end of the pregnancy.
RESULTS
Background variables including maternal age were found to be similarly distributed between the study groups. The rate of maternal and perinatal outcomes including Apgar score and birth weight did not differ significantly between groups. Preeclampsia occurred in 1% of treated women vs 1.78% of control women.
CONCLUSION
Giving supplemental vitamin E from the second trimester of pregnancy did not appear to affect the risk of pregnancy outcomes and occurrence of preeclampsia.
摘要
目的
关于补充维生素 E 在正常妊娠中的作用的现有证据不足。本研究评估了维生素 E 补充剂对一些妊娠健康指标的潜在益处。
方法
采用 1:2 加权简单随机化技术将 104 名符合条件的孕妇分配为接受维生素 E 治疗组（n=104）和未接受药物治疗的对照组（n=168）。从妊娠第 14 周开始，治疗组孕妇服用含有 400IU 维生素 E 的胶囊，直至妊娠结束。
结果
研究组之间的背景变量（包括母亲年龄）分布相似。两组间产妇和围产儿结局（包括阿普加评分和出生体重）的发生率无显著差异。治疗组子痫前期的发生率为 1%，对照组为 1.78%。
结论
从妊娠中期开始补充维生素 E 似乎不会增加妊娠结局和子痫前期的发生风险。
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本文引用的文献
1
Role of oxidative stress in the pathogenesis of preeclampsia.氧化应激在子痫前期发病机制中的作用。
Arch Gynecol Obstet. 2010 Nov;282(5):469-74. doi: 10.1007/s00404-010-1538-6. Epub 2010 Jun 15.
2
Preeclampsia and future maternal health.子痫前期与未来的母婴健康。
J Hypertens. 2010 Jul;28(7):1349-55. doi: 10.1097/HJH.0b013e32833a39d0.
3
Vitamins C and E to prevent complications of pregnancy-associated hypertension.维生素 C 和维生素 E 可预防妊娠相关性高血压并发症。
N Engl J Med. 2010 Apr 8;362(14):1282-91. doi: 10.1056/NEJMoa0908056.
4
An international trial of antioxidants in the prevention of preeclampsia (INTAPP).抗氧化剂预防子痫前期的国际试验（INTAPP）。
Am J Obstet Gynecol. 2010 Mar;202(3):239.e1-239.e10. doi: 10.1016/j.ajog.2010.01.050.
5
Vitamin E: the shrew waiting to be tamed.维生素E：等待被驯服的泼妇。
Free Radic Biol Med. 2009 Mar 1;46(5):543-54. doi: 10.1016/j.freeradbiomed.2008.12.007. Epub 2008 Dec 24.
6
ON THE EXISTENCE OF A HITHERTO UNRECOGNIZED DIETARY FACTOR ESSENTIAL FOR REPRODUCTION.论一种迄今未被认识的对繁殖至关重要的饮食因素的存在。
Science. 1922 Dec 8;56(1458):650-1. doi: 10.1126/science.56.1458.650.
7
8
Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children.孕期母亲维生素E摄入量低与5岁儿童哮喘有关。
Am J Respir Crit Care Med. 2006 Sep 1;174(5):499-507. doi: 10.1164/rccm.200512-1946OC. Epub 2006 Jun 8.
9
Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial.维生素C和维生素E用于先兆子痫高危孕妇（VIP试验）：随机安慰剂对照试验
Lancet. 2006 Apr 8;367(9517):1145-54. doi: 10.1016/S0140-6736(06)68433-X.
10
Vitamin E supplementation in pregnancy.孕期补充维生素E。
Cochrane Database Syst Rev. 2005 Apr 18(2):CD004069. doi: 10.1002/14651858.CD004069.pub2.
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