来自木菠萝根的类黄酮。

Flavonoids from the roots of Artocarpus heterophyllus.

作者信息

Yuan Wen-Jun, Yuan Jin-Bin, Peng Jia-Bing, Ding Yuan-Qing, Zhu Ji-Xiao, Ren Gang

机构信息

Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.

Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.

出版信息

Fitoterapia. 2017 Mar;117:133-137. doi: 10.1016/j.fitote.2017.01.016. Epub 2017 Feb 3.

DOI:10.1016/j.fitote.2017.01.016

PMID:28163073

Abstract

Four new flavonoids, artoheteroids A-D (1-4), together with six known ones (5-10), were isolated from the roots of Artocarpus heterophyllus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Among them, compounds 1-2, 4-6, and 10 were found to have suppression capabilities against CatK with IC values ranging from 1.4 to 93.9μM.

摘要

从菠萝蜜的根部分离出四种新的黄酮类化合物，即菠萝蜜异黄酮A-D（1-4），以及六种已知的化合物（5-10）。通过光谱方法，包括一维和二维核磁共振、紫外、红外、圆二色和高分辨电喷雾电离质谱对它们的结构进行了鉴定。对所有分离出的化合物进行了组织蛋白酶K（CatK）抑制能力的筛选。其中，发现化合物1-2、4-6和10对CatK具有抑制能力，其半数抑制浓度值在1.4至93.9μM之间。