He Jun-Wei, Yang Li, Mu Zhen-Qiang, Zhu Yu-Ye, Zhong Guo-Yue, Liu Zhi-Yong, Zhou Qing-Guang, Cheng Fang
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine Nanchang 330004 China.
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine Nanchang 330004 China
RSC Adv. 2018 May 17;8(32):18175-18179. doi: 10.1039/c8ra00443a. eCollection 2018 May 14.
was a traditional Chinese medicinal plant used to treat inflammation-related diseases with little scientific validation. Twelve flavonoids, including two new compounds namely plantanones A (1) and B (2), were isolated from the flowers of . Their structures were elucidated by NMR and HRMS as well as comparison with literature data. All of the isolated compounds showed significant inhibitory activities against ovine COX-1 and COX-2 at a concentration of 50 μM, with inhibition ratios from 53.00% to 80.55% for COX-1 and from 52.19% to 66.29% for COX-2. Further detailed testing showed that compounds 1, 2, 4 and 12 inhibited the COX-1 and COX-2 enzymes with IC values 12.90-33.37 μM and 38.32-46.16 μM, respectively. Moreover, the antioxidant effects of these isolates against DPPH free radical-scavenging were also evaluated , and a tight structure-activity relationship was discussed. Our results suggested that the anti-inflammatory and antioxidant activities of flowers are partly attributed to these flavonoids.
是一种传统的中国药用植物，用于治疗与炎症相关的疾病，但几乎没有科学验证。从其花中分离出了12种黄酮类化合物，包括两种新化合物，即普兰酮A（1）和B（2）。通过核磁共振（NMR）、高分辨质谱（HRMS）以及与文献数据比较对它们的结构进行了阐明。所有分离出的化合物在浓度为50 μM时对绵羊COX-1和COX-2均表现出显著的抑制活性，COX-1的抑制率为53.00%至80.55%，COX-2的抑制率为52.19%至66.29%。进一步的详细测试表明，化合物1、2、4和12对COX-1和COX-2酶的抑制常数（IC）值分别为12.90 - 33.37 μM和38.32 - 46.16 μM。此外，还评估了这些分离物对二苯基苦味酰基自由基（DPPH）清除的抗氧化作用，并讨论了紧密的构效关系。我们的结果表明，其花的抗炎和抗氧化活性部分归因于这些黄酮类化合物。
