肉花卫矛茎中的抗炎五环三萜类化合物。

Anti-inflammatory pentacyclic triterpenes from the stems of Euonymus carnosus.

作者信息

Zhou Jian, Wei Xiao-Hua, Chen Fang-You, Li Chuang-Jun, Yang Jing-Zhi, Ma Jie, Bao Xiu-Qi, Zhang Dan, Zhang Dong-Ming

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

出版信息

Fitoterapia. 2017 Apr;118:21-26. doi: 10.1016/j.fitote.2017.01.015. Epub 2017 Feb 2.

DOI:10.1016/j.fitote.2017.01.015

PMID:28163075

Abstract

Three new lupane-type triterpenoids (1-3), three new oleane-type triterpenoids (4-6), as well as two known compounds (7-8) were isolated from Euonymus carnosus. The structures of the compounds were elucidated on the basis of spectroscopic data analyses, including UV, IR, MS, and NMR experiments. The inhibitory on LPS-induced NO production in microglia BV2 cells of compounds 1-8 were also evaluated. Compounds 1 and 2 showed moderate abilities to inhibit NO production, with IC values of 5.99 and 8.47μM, respectively.

摘要

从肉花卫矛中分离得到三个新的羽扇豆烷型三萜（1-3）、三个新的齐墩果烷型三萜（4-6）以及两个已知化合物（7-8）。通过紫外光谱（UV）、红外光谱（IR）、质谱（MS）和核磁共振（NMR）等光谱数据分析确定了这些化合物的结构。同时评估了化合物1-8对小胶质细胞BV2细胞中脂多糖（LPS）诱导的一氧化氮（NO）产生的抑制作用。化合物1和2表现出中等程度的抑制NO产生的能力，其半数抑制浓度（IC）值分别为5.99和8.47μM。