从委陵菜中提取具有抑制一氧化氮活性的五环三萜。
Pentacyclic triterpenes with nitric oxide inhibitory activity from Potentilla chinensis.
机构信息
College of Pharmacy, Chungbuk National University, Cheongju 28610, South Korea.
College of Pharmacy, Chungbuk National University, Cheongju 28610, South Korea.
出版信息
Bioorg Chem. 2021 Mar;108:104659. doi: 10.1016/j.bioorg.2021.104659. Epub 2021 Jan 21.
Three new ursane-type triterpenes (1-3) and twenty-one known triterpenoids (4-24) were isolated from the methanolic extract of the whole plants of Potentilla chinensis. Their structures were elucidated by extensive spectroscopic analysis of 1D and 2D NMR (HSQC, HMBC, COSY and ROESY) and HRESIMS data. The bioassay screening revealed the inhibitory effects on nitric oxide production of compounds 2, 5, 7, 9, 10, and 13-24 in LPS-induced RAW264.7 macrophages.
从委陵菜全草的甲醇提取物中分离得到了三种新的五环三萜（1-3）和二十一种已知的三萜（4-24）。通过对 1D 和 2D NMR（HSQC、HMBC、COSY 和 ROESY）和 HRESIMS 数据的广泛光谱分析，阐明了它们的结构。生物测定筛选显示，化合物 2、5、7、9、10 和 13-24 对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮生成具有抑制作用。
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