Kajiyama Hiroaki, Utsumi Fumi, Nakamura Kae, Tanaka Hiromasa, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan.
Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan; Plasma Nanotechnology Research Center, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
J Clin Biochem Nutr. 2017 Jan;60(1):33-38. doi: 10.3164/jcbn.16-65. Epub 2016 Dec 17.
The therapeutic effects of non-thermal plasma are expected in the medical fields, including hemostasis, vascularization, prevention of organ adhesion, and cell proliferation. Cancer is an internal enemy arising from normal tissue in the body. The prognosis of metastatic and recurrent cancers is still poor despite advances in medicine. To apply non-thermal plasma in cancer treatment is now on going. The mechanism of the proliferation-inhibitory effect of plasma is reactive nitrogen oxide species/reactive oxygen species production in cells. There are a number of problems to be overcome, such as existence of intrinsic reactive oxygen species/reactive nitrogen species scavengers and the shallow infiltration of plasma on tumor surface. The current reviews makes referral to the study results of plasma therapy clarified so far, the possibility of its application in the future.
非热等离子体的治疗效果在包括止血、血管生成、预防器官粘连和细胞增殖等医学领域受到期待。癌症是身体中正常组织产生的内部敌人。尽管医学取得了进步，但转移性和复发性癌症的预后仍然很差。目前正在进行将非热等离子体应用于癌症治疗的研究。等离子体增殖抑制作用的机制是细胞中活性氮氧化物/活性氧物种的产生。仍有许多问题需要克服，例如存在内源性活性氧/活性氮清除剂以及等离子体在肿瘤表面的渗透较浅。本综述参考了迄今为止已阐明的等离子体疗法的研究结果及其未来应用的可能性。
