Danza F M, Falcione M, Bordonaro V, Infante A, Paladini A, Bonomo L
Diagnostic Imaging Area, Catholic University of the Sacred Heart, School of Medicine, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2017 Jan;21(2):408-415.
To present the results of our ten-year case series in simple hepatic and renal cysts sclerosis using minocycline hydrochloride as a sclerotizing agent, evaluating the effectiveness, the safety and the feasibility of this agent for percutaneous sclerotherapy for symptomatic cysts.
We retrospectively evaluated our archives of patients treated (54 patients with 60 renal cysts, 21 patients with 24 hepatic cysts) for symptomatic abdominal cysts. These patients were treated with ultrasound guided drainage and subsequent minocycline hydrochloride instillation. In large or recurrent cysts, we repeated the treatment for the second time. The patients were evaluated at 6 and 12 months; some patients underwent later, additional examinations and we also reviewed these exams for any eventual long-term relapse.
The percentage of sclerosis success was found to be 100% for hepatic cysts and 86% for renal cysts. We also found that minimal complications were encountered.
Minocycline hydrochloride has proven to be an effective sclerotizing agent. In our cases, symptoms disappeared in 100% of patients with hepatic cysts and in 93% of patients with renal cysts. It is also a safe sclerotizing agent, as demonstrated by the few complications encountered. Percutaneous sclerosis with Minocycline hydrochloride is a very effective and promising nonsurgical treatment for patients with symptomatic simple cysts, and it can be performed without major complications.
介绍我们使用盐酸米诺环素作为硬化剂治疗单纯性肝囊肿和肾囊肿硬化症的十年病例系列结果，评估该药物用于有症状囊肿经皮硬化治疗的有效性、安全性和可行性。
我们回顾性评估了接受治疗的有症状腹部囊肿患者档案（54例患者有60个肾囊肿，21例患者有24个肝囊肿）。这些患者接受了超声引导下引流及随后的盐酸米诺环素灌注。对于大囊肿或复发性囊肿，我们进行了第二次重复治疗。在6个月和12个月时对患者进行评估；一些患者后来接受了额外检查，我们也复查了这些检查以查看是否有任何最终的长期复发情况。
发现肝囊肿硬化成功率为100%，肾囊肿为86%。我们还发现并发症极少。
盐酸米诺环素已被证明是一种有效的硬化剂。在我们的病例中，100%的肝囊肿患者和93%的肾囊肿患者症状消失。它也是一种安全的硬化剂，如所遇到的极少并发症所示。盐酸米诺环素经皮硬化治疗对于有症状的单纯囊肿患者是一种非常有效且有前景的非手术治疗方法，并且可以在无重大并发症的情况下进行。
