Cellier C, Cuenod C A, Deslandes P, Auroux J, Landi B, Siauve N, Barbier J P, Frija G
Department of Gastroenterology, Université René Descartes, Hôpital Laennec, Paris, France.
Radiology. 1998 Jan;206(1):205-9. doi: 10.1148/radiology.206.1.9423674.
To assess the efficacy of percutaneous minocycline hydrochloride sclerotherapy in symptomatic hepatic cysts.
From November 1992 to June 1994, seven of eight consecutive adults with large symptomatic hepatic cysts (diameter, 55-130 mm) were treated with a single intracystic injection of minocycline hydrochloride in an ambulatory procedure. Five patients had a solitary cyst, and two had polycystic liver disease. The target cyst was punctured under ultrasound guidance and local anesthesia with a 22-gauge Chiba needle. Half of the cyst content was aspirated before injection of 100-500 mg of minocycline hydrochloride diluted in 5-25 mL of saline. The minocycline hydrochloride was left in the cyst at the end of the procedure.
After a mean follow-up of 28 months (range, 24-42 months), all five patients with solitary cysts were asymptomatic and four had documented complete cyst regression; the two patients with multiple hepatic cysts showed only transient clinical improvement.
Single-shot injection of minocycline hydrochloride is an effective treatment for symptomatic solitary hepatic cysts but is less effective in polycystic liver disease.
评估经皮注射盐酸米诺环素硬化疗法治疗有症状肝囊肿的疗效。
1992年11月至1994年6月，连续8例有症状的大肝囊肿（直径55 - 130 mm）成人患者中的7例，在门诊接受了单次囊内注射盐酸米诺环素治疗。5例患者为单个囊肿，2例为多囊肝病。在超声引导和局部麻醉下，用22号千叶针穿刺目标囊肿。在注入稀释于5 - 25 mL盐水中的100 - 500 mg盐酸米诺环素之前，先抽出一半囊液。操作结束时将盐酸米诺环素留在囊肿内。
平均随访28个月（范围24 - 42个月）后，所有5例单个囊肿患者均无症状，4例囊肿完全消退；2例多囊肝患者仅表现为短暂的临床改善。
单次注射盐酸米诺环素是治疗有症状的单个肝囊肿的有效方法，但对多囊肝病疗效较差。
Zotero 插件