Department of Chemical Engineering, Islamic Azad University, P.O. Box 97177-11111, Birjand, Iran.
Institute of Nanoscience and Nanotechnology, University of Kashan, Kashan, Iran.
Int J Biol Macromol. 2017 May;98:287-291. doi: 10.1016/j.ijbiomac.2017.02.012. Epub 2017 Feb 3.
The combination of imaging and delivery systems through nanoscale material have been used to create new nanoparticle formulations for biological applications. Here, a magnetic nanocomposite consisting of superparamagnetic iron oxide nanoparticles (SPIONs), graphene oxide (GO), chitosan and poly(vinyl alcohol) (PVA) as biocompatible polymers was synthesized for applying in drug delivery and imaging agent. The nanocomposite was studied by various techniques including XRD, TEM, FE-SEM, FT-IR and VSM. SPIONs had an average diameter size about 10nm and showed superparamagnetic behavior. Also, TEM and SEM images showed that these nanoparticles successfully attached on the surface of GO sheets. Finally, 5-fu was loaded onto these nanocomposite particles in order to study of entrapment efficiency and drug release behavior of nanocomposite particles. They showed high drug entrapment efficiency and more and faster drug release in acidic pH.
通过纳米材料将成像和输送系统结合起来，已经被用于为生物应用创造新的纳米颗粒制剂。在这里，合成了一种由超顺磁性氧化铁纳米粒子（SPIONs）、氧化石墨烯（GO）、壳聚糖和聚乙烯醇（PVA）作为生物相容性聚合物组成的磁性纳米复合材料，用于药物输送和成像剂。通过 XRD、TEM、FE-SEM、FT-IR 和 VSM 等多种技术对纳米复合材料进行了研究。SPIONs 的平均直径约为 10nm，表现出超顺磁性。此外，TEM 和 SEM 图像表明，这些纳米粒子成功地附着在 GO 片的表面上。最后，将 5-氟尿嘧啶载入这些纳米复合材料颗粒中，以研究纳米复合材料颗粒的包封效率和药物释放行为。它们表现出高的药物包封效率和在酸性 pH 值下更快更多的药物释放。
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