Department of Materials Science and Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, England.
Department of Materials Science and Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, England.
Carbohydr Polym. 2014 Mar 15;103:70-80. doi: 10.1016/j.carbpol.2013.12.012. Epub 2013 Dec 12.
Biodegradable chitosan-graphene oxide (GO) nanocomposites possess improved mechanical properties and drug delivery performance over chitosan and could prove to be a viable, controlled and pH-sensitive transdermal drug delivery system. Chitosan nanocomposites containing varying GO contents and drug loading ratios were investigated. The nanocomposite with 2 wt % GO provided the optimal combination of mechanical properties and drug-loading capacity. It offered a faster and a more substantial release of drug than chitosan as well as a slower biodegradation rate, owing to the abundant oxygenated functional groups, hydrophilicity and large specific surface area of GO sheets. The drug delivery profiles of the nanocomposite were dependent on the drug loading ratio, with 0.84:1 being the best ratio of drug to GO for a quick and high release of the loaded drug. The nanocomposite also demonstrated pH sensitivity of drug release, releasing 48% less drug in an acidic condition than in a neutral environment.
可生物降解的壳聚糖-氧化石墨烯（GO）纳米复合材料具有优于壳聚糖的机械性能和药物输送性能，有望成为一种可行的、可控的和 pH 敏感的透皮药物输送系统。研究了含有不同 GO 含量和载药比例的壳聚糖纳米复合材料。含有 2wt%GO 的纳米复合材料提供了机械性能和载药能力的最佳组合。由于 GO 片丰富的含氧官能团、亲水性和大的比表面积，它提供了比壳聚糖更快、更大量的药物释放以及更慢的生物降解速率。纳米复合材料的药物释放特性取决于载药比例，当药物与 GO 的比例为 0.84:1 时，载药的快速和高释放效果最佳。纳米复合材料还表现出对药物释放的 pH 敏感性，在酸性条件下释放的药物比在中性环境中少 48%。
