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扭转结核病蔓延态势。

Turning the tide against tuberculosis.

机构信息

South African Medical Research Council HIV-TB Pathogenesis and Treatment Research Unit, CAPRISA, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Private Bag X7, Congella 4013, South Africa.

South African Medical Research Council HIV-TB Pathogenesis and Treatment Research Unit, CAPRISA, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Private Bag X7, Congella 4013, South Africa.

出版信息

Int J Infect Dis. 2017 Mar;56:6-9. doi: 10.1016/j.ijid.2017.01.012. Epub 2017 Feb 4.

DOI:10.1016/j.ijid.2017.01.012
PMID:28167256
Abstract

Despite affecting men, women, and children for millennia, tuberculosis (TB) is the most neglected disease. In contrast, the global response to HIV has reached a defining moment. By uniting efforts, promptly integrating major scientific findings for both treatment and prevention, and scaling up services, the once inconceivable end to the HIV epidemic may no longer be an illusion. "The world has made defeating AIDS a top priority. This is a blessing. But TB remains ignored" - Nelson Mandela. While there is no doubt that revolutionary diagnostics and new and repurposed drugs have provided some hope in the fight against TB, it is evident that scientific advances on their own are inadequate to achieve the World Health Organization's ambitious goal to end TB by 2035. In this article, the consequences of a myopic and conventional biomedical approach to TB, which has ultimately permeated to the level of individual patient care, are highlighted.

摘要

尽管结核病(TB)已经影响了数千年的男性、女性和儿童,但它是最被忽视的疾病。相比之下,全球对艾滋病毒的应对措施已经达到了一个决定性的时刻。通过共同努力,及时整合治疗和预防方面的主要科学发现,并扩大服务范围,曾经难以想象的终结艾滋病毒流行的目标可能不再是幻想。“世界已经将战胜艾滋病作为首要任务。这是一种祝福。但结核病仍然被忽视”——纳尔逊·曼德拉。虽然毫无疑问,革命性的诊断技术以及新的和重新利用的药物为抗击结核病提供了一些希望,但很明显,仅凭科学进步不足以实现世界卫生组织到 2035 年终结结核病的宏伟目标。在本文中,强调了一种短视和传统的生物医学方法对结核病的影响,这种方法最终渗透到了个体患者护理的层面。

相似文献

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Turning the tide against tuberculosis.扭转结核病蔓延态势。
Int J Infect Dis. 2017 Mar;56:6-9. doi: 10.1016/j.ijid.2017.01.012. Epub 2017 Feb 4.
2
Plan to combat extensively drug-resistant tuberculosis: recommendations of the Federal Tuberculosis Task Force.抗击广泛耐药结核病计划:联邦结核病特别工作组的建议
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Shifting from tuberculosis control to elimination: Where are we? What are the variables and limitations? Is it achievable?从结核病控制到消除:我们在哪里?有哪些变量和限制?这是否可行?
Int J Infect Dis. 2017 Mar;56:30-33. doi: 10.1016/j.ijid.2016.11.416. Epub 2016 Dec 1.
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Extensively drug-resistant (XDR) tuberculosis: an old and new threat.广泛耐药结核病:一种新老威胁并存的疾病
Ann Ist Super Sanita. 2007;43(4):317-9.
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Management of drug resistantTB in patients with HIV co-infection.合并感染HIV的耐药结核病患者的管理。
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Southern Africa is moving swiftly to combat the threat of XDR-TB.南部非洲正在迅速采取行动应对广泛耐药结核病的威胁。
Bull World Health Organ. 2006 Dec;84(12):924-5.
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Evaluation of the intensified tuberculosis case finding guidelines for children living with HIV.评价针对艾滋病毒感染儿童的强化结核病病例发现指南。
Int J Tuberc Lung Dis. 2018 Nov 1;22(11):1322-1328. doi: 10.5588/ijtld.17.0825.
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API TB Consensus Guidelines 2006: Management of pulmonary tuberculosis, extra-pulmonary tuberculosis and tuberculosis in special situations.《2006年抗结核药物国际共识指南:肺结核、肺外结核及特殊情况结核病的管理》
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Tuberculosis and human immunodeficiency virus infection in developing countries.发展中国家的结核病与人类免疫缺陷病毒感染
Lancet. 1990 Feb 17;335(8686):387-90. doi: 10.1016/0140-6736(90)90216-r.
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Advances in tuberculosis 2011-2012.2011-2012 年结核病研究进展。
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