Yoo Seung-Woo, Lee Inah
Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Korea.
Elife. 2017 Feb 7;6:e21543. doi: 10.7554/eLife.21543.
How visual scene memory is processed differentially by the upstream structures of the hippocampus is largely unknown. We sought to dissociate functionally the lateral and medial subdivisions of the entorhinal cortex (LEC and MEC, respectively) in visual scene-dependent tasks by temporarily inactivating the LEC and MEC in the same rat. When the rat made spatial choices in a T-maze using visual scenes displayed on LCD screens, the inactivation of the MEC but not the LEC produced severe deficits in performance. However, when the task required the animal to push a jar or to dig in the sand in the jar using the same scene stimuli, the LEC but not the MEC became important. Our findings suggest that the entorhinal cortex is critical for scene-dependent mnemonic behavior, and the response modality may interact with a sensory modality to determine the involvement of the LEC and MEC in scene-based memory tasks.
海马体上游结构如何对视觉场景记忆进行差异处理在很大程度上尚不清楚。我们试图通过在同一只大鼠中暂时使内嗅皮层的外侧和内侧亚区（分别为LEC和MEC）失活，在依赖视觉场景的任务中从功能上区分它们。当大鼠在T型迷宫中利用液晶屏幕上显示的视觉场景做出空间选择时，MEC而非LEC失活会导致严重的行为表现缺陷。然而，当任务要求动物使用相同的场景刺激推动罐子或在罐子里的沙子中挖掘时，LEC而非MEC变得至关重要。我们的研究结果表明，内嗅皮层对于依赖场景的记忆行为至关重要，并且反应方式可能与感觉方式相互作用，以确定LEC和MEC在基于场景的记忆任务中的参与情况。
