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一种用于检测细胞内源性酪氨酸酶活性的高灵敏度和高选择性荧光开-关探针。

A highly sensitive and selective fluorescence off-on probe for the detection of intracellular endogenous tyrosinase activity.

作者信息

Wu Xiaofeng, Li Xiaohua, Li Hongyu, Shi Wen, Ma Huimin

机构信息

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

出版信息

Chem Commun (Camb). 2017 Feb 21;53(16):2443-2446. doi: 10.1039/c6cc09679d.

DOI:10.1039/c6cc09679d
PMID:28174769
Abstract

A resorufin-based highly sensitive and selective fluorescence off-on probe with a new recognition moiety for tyrosinase is developed, and applied to detect and image endogenous tyrosinase activity in different living cells.

摘要

开发了一种基于试卤灵的高灵敏度和选择性荧光开-关探针，其具有用于酪氨酸酶的新识别部分，并应用于检测和成像不同活细胞中的内源性酪氨酸酶活性。

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