Harris M C, Kolski G B, Campbell D E, Deuber C, Marcus M, Douglas S D
Division of Neonatology, Children's Hospital of Philadelphia, Pennsylvania.
Ann Allergy. 1989 Nov;63(5):439-43.
Twenty-nine infants were followed prospectively for the development of immunoglobulin G (IgG) and IgE antibodies to the cow milk proteins (CMPs) alpha-lactalbumin, alpha-casein, and beta-lactoglobulin. Thirteen infants were fed formula, eight were exclusively breast fed, and eight were breast fed with formula supplementation. By 4 months of life, infants fed formula or breast milk with formula supplementation had elevated IgE and IgG antibody levels to CMPs, when compared with values before 1 month of age. Further, breast-fed infants demonstrated significantly lower levels of IgE and IgG antibodies to CMPs than infants who received formula or breast milk with formula supplementation. Clinical symptoms of cow milk allergy were more common in infants fed formula or breast fed with supplementation, but were not significantly related to the presence of specific antibody. Our data suggest that the formation of CMP antibodies may reflect a normal humoral response following exposure to CMP antigens in this age group.
对29名婴儿进行了前瞻性跟踪，观察其针对牛奶蛋白（CMP）α-乳白蛋白、α-酪蛋白和β-乳球蛋白的免疫球蛋白G（IgG）和IgE抗体的发育情况。13名婴儿喂养配方奶，8名婴儿纯母乳喂养，8名婴儿母乳喂养并添加配方奶。到4月龄时，与1月龄前的值相比，喂养配方奶或母乳喂养并添加配方奶的婴儿针对CMP的IgE和IgG抗体水平升高。此外，母乳喂养的婴儿针对CMP的IgE和IgG抗体水平明显低于接受配方奶或母乳喂养并添加配方奶的婴儿。牛奶过敏的临床症状在喂养配方奶或母乳喂养并添加配方奶的婴儿中更常见，但与特异性抗体的存在无显著相关性。我们的数据表明，CMP抗体的形成可能反映了该年龄组接触CMP抗原后正常的体液反应。
