Riber E, Kaaber S
Scand J Dent Res. 1978 Sep;86(5):386-91. doi: 10.1111/j.1600-0722.1978.tb00641.x.
The barrier property of inflamed palatal mucosa to water has been studied in eight adult edentulous persons with a generalized denture stomatitis, by measuring the transmucosal water flow under varying osmotic gradients. Flow rates were registered gravimetrically in solute saturated filter paper discs after 10-min periods of mucosal contact, using solutions with an osmolarity of 0, 0.25, 0.30, 0.38, 0.50 and 0.75 osmol sucrose/l. The histology of the mucosal areas was evaluated from cytologic scrapings, and biopsy material from two persons. The inflow with use of pure water was 2.98 mg/cm2/10 min, being about three and a half times greater than through the intact mucosal surface. The point of isotony of the inflamed mucosa ranged between 0.30 and 0.36 with a mean value of 0.33 osmol/l, thus being of the same magnitude as in plasma and tissue fluid. The observations from the biopsy material were in accordance with earlier histological evidence from generalized denture stomatitis, indicating that the permeability properties of the inflamed mucosa belonged to epithelial cell layers located in the lower part of the spinous layer.
通过测量在不同渗透梯度下的跨黏膜水流，对8名患有广泛性义齿性口炎的成年无牙患者发炎的腭黏膜的水屏障特性进行了研究。在黏膜接触10分钟后，使用渗透压为0、0.25、0.30、0.38、0.50和0.75摩尔蔗糖/升的溶液，通过重量法记录溶质饱和滤纸圆盘中的流速。从细胞学刮片以及两名患者的活检材料对黏膜区域的组织学进行了评估。使用纯水时的流入量为2.98毫克/平方厘米/10分钟，约为通过完整黏膜表面流入量的三倍半。发炎黏膜的等渗点在0.30至0.36之间，平均值为0.33摩尔/升，因此与血浆和组织液中的等渗点大小相同。活检材料的观察结果与先前关于广泛性义齿性口炎的组织学证据一致，表明发炎黏膜的通透性特性属于位于棘层下部的上皮细胞层。
