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用于改善动脉粥样硬化斑块 F-NaF 成像中 PET 定量的部分容积校正。

Partial volume correction for improved PET quantification in F-NaF imaging of atherosclerotic plaques.

机构信息

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, General Hospital Vienna, Waehringer Guertel 18-20/4L, 1090, Vienna, Austria.

Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

出版信息

J Nucl Cardiol. 2018 Oct;25(5):1742-1756. doi: 10.1007/s12350-017-0778-2. Epub 2017 Feb 7.

DOI:10.1007/s12350-017-0778-2
PMID:28176255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6153866/
Abstract

BACKGROUND

Accurate quantification of plaque imaging using F-NaF PET requires partial volume correction (PVC).

METHODS

PVC of PET data was implemented by the use of a local projection (LP) method. LP-based PVC was evaluated with an image quality (NEMA) and with a thorax phantom with "plaque-type" lesions of 18-36 mL. The validated PVC method was then applied to a cohort of 17 patients, each with at least one plaque in the carotid or ascending aortic arteries. In total, 51 calcified (HU > 110) and 16 non-calcified plaque lesions (HU < 110) were analyzed. The lesion-to-background ratio (LBR) and the relative change of LBR (ΔLBR) were measured on PET.

RESULTS

Following PVC, LBR of the spheres (NEMA phantom) was within 10% of the original values. LBR of the thoracic lesions increased by 155% to 440% when the LP-PVC method was applied to the PET images. In patients, PVC increased the LBR in both calcified [mean = 78% (-8% to 227%)] and non-calcified plaques [mean = 41%, (-9%-104%)].

CONCLUSIONS

PVC helps to improve LBR of plaque-type lesions in both phantom studies and clinical patients. Better results were obtained when the PVC method was applied to images reconstructed with point spread function modeling.

摘要

背景

使用 F-NaF PET 对斑块成像进行准确量化需要部分容积校正（PVC）。

方法

通过使用局部投影（LP）方法实现 PET 数据的 PVC。使用图像质量（NEMA）和具有“斑块型”病变的胸腔体模（18-36 mL）评估基于 LP 的 PVC。然后将经过验证的 PVC 方法应用于 17 名患者的队列中，每个患者的颈动脉或升主动脉中至少有一个斑块。总共分析了 51 个钙化（HU>110）和 16 个非钙化斑块病变（HU<110）。在 PET 上测量病变与背景的比值（LBR）和 LBR 的相对变化（ΔLBR）。

结果

经过 PVC 后，球体的 LBR（NEMA 体模）在原始值的 10%以内。当将 LP-PVC 方法应用于 PET 图像时，胸腔病变的 LBR 增加了 155%至 440%。在患者中，PVC 增加了钙化斑块的 LBR[平均值=78%（-8%至 227%）]和非钙化斑块的 LBR[平均值=41%（-9%至 104%）]。

结论

PVC 有助于改善体模研究和临床患者中斑块型病变的 LBR。当将 PVC 方法应用于使用点扩散函数建模重建的图像时，会获得更好的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/e26fce52040f/12350_2017_778_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/254d4679533a/12350_2017_778_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/6a39216eaded/12350_2017_778_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/b62c79af7bbc/12350_2017_778_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/51197229e2c5/12350_2017_778_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/0b5304829e38/12350_2017_778_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/e26fce52040f/12350_2017_778_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/254d4679533a/12350_2017_778_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/6a39216eaded/12350_2017_778_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/b62c79af7bbc/12350_2017_778_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/51197229e2c5/12350_2017_778_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/0b5304829e38/12350_2017_778_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b465/6153866/e26fce52040f/12350_2017_778_Fig6_HTML.jpg

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