Fazio V W, Galandiuk S, Jagelman D G, Lavery I C
Department of Colon and Rectal Surgery, Cleveland Clinic Foundation, Ohio 44195.
Ann Surg. 1989 Nov;210(5):621-5. doi: 10.1097/00000658-198911000-00009.
Fifty patients with fibrotic small bowel strictures secondary to long-standing Crohn's disease underwent a total of 225 strictureplasties during the period from June 1984 to July 1988. Forty-two patients (84%) presented with obstructive symptoms. Patients had a 1- to 30-year history of Crohn's disease (mean, 14 years). Sixty-two per cent of patients were taking steroids at the time of admission, and 70% had had previous small bowel resections. All patients had one or more areas of small bowel affected with a fibrotic stricture and partial obstruction. Short strictures were treated by Heinecke-Mikulicz strictureplasties, and longer strictures by Finney side-to-side strictureplasties. In 30 patients (60%), 6- to 65-cm segments of small bowel were also resected due to acute inflammation with phlegmon or fistulae. Patients were discharged from the hospital 5 to 20 days after operation (mean, 10 days). After operation all patients with obstructive symptoms reported relief of symptoms and weight gain. Steroid doses could be tapered and nutritional parameters, such as total lymphocyte count, and serum albumin improved. Strictureplasty had 0% mortality and 16% morbidity rates. Complications included 3 enterocutaneous fistulae, 2 intra-abdominal abscesses, 2 hemorrhages requiring transfusion, 1 prolonged postoperative ileus that could be treated conservatively in 2 patients, and 1 restricture of a strictureplasty. Patients were followed for 1 to 40 months after operation (mean, 8 months). Resection of small bowel disease, especially that associated with perforation, is usually required in Crohn's disease. However, strictureplasty minimizes the need for bowel resection in patients with short fibrotic strictures resulting in recurrent small bowel obstruction.
1984年6月至1988年7月期间,50例因长期克罗恩病继发纤维化小肠狭窄的患者共接受了225次狭窄成形术。42例患者(84%)出现梗阻症状。患者有1至30年的克罗恩病病史(平均14年)。62%的患者入院时正在服用类固醇,70%的患者曾接受过小肠切除术。所有患者均有一个或多个小肠区域受纤维化狭窄和部分梗阻影响。短狭窄采用海涅克-米库利奇狭窄成形术治疗,长狭窄采用芬尼侧侧狭窄成形术治疗。30例患者(60%)因急性炎症伴蜂窝织炎或瘘管还切除了6至65厘米的小肠段。患者术后5至20天出院(平均10天)。术后所有有梗阻症状的患者均报告症状缓解且体重增加。类固醇剂量可逐渐减少,总淋巴细胞计数和血清白蛋白等营养参数有所改善。狭窄成形术的死亡率为0%,发病率为16%。并发症包括3例肠皮肤瘘、2例腹腔内脓肿、2例需要输血的出血、1例术后肠梗阻延长,其中2例患者可保守治疗,以及1例狭窄成形术后再狭窄。患者术后随访1至40个月(平均8个月)。在克罗恩病中,通常需要切除小肠病变,尤其是与穿孔相关的病变。然而,对于因短纤维化狭窄导致复发性小肠梗阻的患者,狭窄成形术可将肠切除的需求降至最低。