Albajri Eram, Almasaudi Arwa S, Mosli Hala H, Hakim Noor A, Basaqr Reem O, Naseeb Manal
Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Obesity and Lifestyle Unit, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Diabetol Metab Syndr. 2025 Jan 4;17(1):3. doi: 10.1186/s13098-024-01566-8.
The potential therapeutic role of magnesium (Mg) in type 2 diabetes mellitus (T2DM) remains insufficiently studied despite its known involvement in critical processes like lipid metabolism and insulin sensitivity. This study examines the impact of Mg-focused nutritional education on lipid profile parameters, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.
Thirty participants with T2DM were recruited for this within-subject experimental study. Participants underwent a three-month dietary intervention focused on increasing the intake of Mg-rich foods through nutritional education. Anthropometric measurements and lipids were assessed at baseline and after the intervention period, with the primary outcome variables including changes in lipid parameters.
The findings showed a significant inverse association between dietary Mg intake and total cholesterol levels (r = - 0.36, p = 0.05). However, other parameters, TG, LDL-C, and HDL-C, were not found to be associated with Mg intake.
The study demonstrated an inverse association between Mg intake and cholesterol level. Providing nutritional education and guidance on incorporating Mg-rich foods into the diet may be a crucial strategy for improving the health and well-being of T2DM patients in Saudi Arabia. The feasibility and practicality of focused nutritional education as an intervention make it a low-cost, scalable, and sustainable approach that can be readily implemented in clinical and community settings. Further studies are needed to explore the long-term impact of dietary Mg interventions on a larger sample with longer education periods.
尽管镁(Mg)已知参与脂质代谢和胰岛素敏感性等关键过程,但其在2型糖尿病(T2DM)中的潜在治疗作用仍未得到充分研究。本研究探讨了以镁为重点的营养教育对T2DM患者血脂谱参数、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)的影响。
招募了30名T2DM患者参与这项自身实验性研究。参与者接受了为期三个月的饮食干预,通过营养教育增加富含镁的食物摄入量。在基线和干预期结束后评估人体测量指标和血脂,主要结局变量包括血脂参数的变化。
研究结果显示饮食中镁摄入量与总胆固醇水平之间存在显著负相关(r = -0.36,p = 0.05)。然而,未发现其他参数(TG、LDL-C和HDL-C)与镁摄入量有关。
该研究表明镁摄入量与胆固醇水平呈负相关。提供营养教育并指导将富含镁的食物纳入饮食,可能是改善沙特阿拉伯T2DM患者健康和福祉的关键策略。以营养教育为重点的干预措施的可行性和实用性使其成为一种低成本、可扩展且可持续的方法,可在临床和社区环境中轻松实施。需要进一步研究以探讨饮食中镁干预对更大样本、更长教育期的长期影响。