State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.
Savaid Medical School, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Org Lett. 2017 Feb 17;19(4):942-945. doi: 10.1021/acs.orglett.7b00145. Epub 2017 Feb 9.
Three highly modified indole alkaloids, versicoamides F-H (1-3), together with seven known alkaloids (4-10) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. The absolute configurations of 1 and 2 were assigned by single-crystal X-ray diffraction experiments. Compounds 1 and 2 showed weak antiproliferative activity against the H460 cell line. Compounds 1-3 represent a new class of natural product hybrids with new chemical skeletons.
从曲霉属真菌中分离得到三种高度修饰的吲哚生物碱，即 versicoamides F-H（1-3），以及七种已知生物碱（4-10）。通过 NMR 和 MS 光谱数据分析确定了新化合物的结构。通过单晶 X 射线衍射实验确定了 1 和 2 的绝对构型。化合物 1 和 2 对 H460 细胞系表现出较弱的抗增殖活性。化合物 1-3 代表一类具有新化学骨架的新型天然产物杂合体。
