挖掘土曲霉这种真菌内生菌的化学多样性和药用前景：综述

Unearthing the fungal endophyte Aspergillus terreus for chemodiversity and medicinal prospects: a comprehensive review.

作者信息

Amr Khadiga, Ibrahim Nehal, Elissawy Ahmed M, Singab Abdel Nasser B

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street 1, Cairo, 11566, Egypt.

Center of Drug Discovery Research and Development, Ain-Shams University, Organization of African Unity Street 1, Cairo, 11566, Egypt.

出版信息

Fungal Biol Biotechnol. 2023 Mar 25;10(1):6. doi: 10.1186/s40694-023-00153-2.

Aspergillus terreus microorganism represents a promising prospective source for drug discovery since it is rich in diverse kinds of bioactive secondary metabolites. It contributed to many biotechnological applications and its metabolites are used in the synthesis of certain pharmaceuticals and food products, in addition to its useful uses in fermentation processes. There are about 346 compounds identified from marine and terrestrial-derived A. terreus from 1987 until 2022, 172 compounds of them proved a vast array of bioactivity. This review aimed to create an up-to-date comprehensive literature data of A. terreus's secondary metabolites classes supported by its different bioactivity data to be a scientific record for the next work in drug discovery.