Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385, Haeyang-ro, Yeongdo-gu, Busan Metropolitan City 49111, Korea.
Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro Yuseong-gu, Daejeon 34113, Korea.
Mar Drugs. 2018 Jan 5;16(1):14. doi: 10.3390/md16010014.
A new α-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (), and four known secondary metabolites, aspertetranone D (), cycloechinulin (), wasabidienone E (), and mactanamide (), were isolated from the marine fungus derived from a sponge sp. collected in Vietnam. The structures of Compounds - were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP). Compounds - had no anti-proliferative effect on human cancer cell lines up to 30 μg/mL. Among these compounds, aspertetranone D () and wasabidienone E () exhibited weak osteoclast differentiation inhibitory activity at 10 μg/mL. However, mactanamide () showed a potent suppression effect of osteoclast differentiation without any evidence of cytotoxicity.
从越南采集的海绵中分离得到的海洋真菌 中，分离得到了一个具有角四环碳骨架的新的α-吡喃酮倍半萜，即ochraceopone F ()，以及四个已知的次级代谢产物，aspertetranone D ()、cycloechinulin ()、wasabidienone E ()和 mactanamide ()。通过 1D 和 2D NMR 光谱和 MS 数据分析，确定了化合物 - 的结构。所有分离得到的化合物均进行了抗增殖活性评价，并通过抗酒石酸酸性磷酸酶（TRAP）检测其对核因子κB 受体激活剂配体（RANKL）诱导的破骨细胞分化的抑制作用。这些化合物在 30μg/mL 浓度下对人癌细胞系均无明显的增殖抑制作用。其中，aspertetranone D ()和 wasabidienone E ()在 10μg/mL 浓度下对破骨细胞分化具有较弱的抑制活性，而 mactanamide ()则表现出对破骨细胞分化的显著抑制作用，且无细胞毒性。
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