Haboubi Hasan N Y, Diyar Rizwan, Benton Ann, Ch'ng Chin Lye
Department of Hepatology, Singleton Hospital, Sketty Lane, Swansea SA2 8QA, UK.
Department of Haematology, Singleton Hospital, Sketty Lane, Swansea SA2 8QA, UK.
Case Rep Gastrointest Med. 2017;2017:8941218. doi: 10.1155/2017/8941218. Epub 2017 Jan 15.
We present the case of a man who, following immunosuppressive treatment for non-Hodgkin lymphoma, became infected with viral hepatitis E. Acute hepatitis E virus infection should be considered in patients with deranged liver function on a background of haematological malignancies or immunosuppression, even without travel to endemic regions. Whilst clearance is usually spontaneous in immune-competent individuals, these at-risk groups may develop a more complicated and protracted disease course. Thus awareness is important as additional treatment with ribavirin or pegylated interferon may be required, as in this case, in order to help achieve eradication.
我们报告了一例男性病例,该患者在接受非霍奇金淋巴瘤免疫抑制治疗后感染了戊型肝炎病毒。即使没有前往流行地区,对于血液系统恶性肿瘤或免疫抑制背景下肝功能紊乱的患者,也应考虑急性戊型肝炎病毒感染。虽然在免疫功能正常的个体中通常可自发清除病毒,但这些高危人群可能会出现更复杂、病程更长的疾病。因此,提高认识很重要,因为如本病例所示,可能需要使用利巴韦林或聚乙二醇干扰素进行额外治疗,以帮助实现病毒清除。