Theodoroff Sarah M, Griest Susan E, Folmer Robert L
VA RR&D, National Center for Rehabilitative Auditory Research, VA Portland Health Care System, 3710 SW US Veterans Hospital Road (NCRAR - P5), Portland, OR, 97239, USA.
Department of Otolaryngology, Head-Neck-Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
Trials. 2017 Feb 9;18(1):64. doi: 10.1186/s13063-017-1807-9.
Identifying characteristics associated with transcranial magnetic stimulation (TMS) benefit would offer insight as to why some individuals experience tinnitus relief following TMS treatment, whereas others do not. The purpose of this study was to use the Tinnitus Functional Index (TFI) and its subscales to identify specific factors associated with TMS treatment responsiveness.
Individuals with bothersome tinnitus underwent 2000 pulses of 1-Hz TMS for 10 consecutive business days. The primary outcome measure was the TFI which yields a total score and eight individual subscale scores. Analyses were performed on baseline data from the active arm (n = 35) of a prospective, double-blind, randomized placebo-controlled clinical trial of TMS for tinnitus.
Baseline total TFI score and three of the eight TFI subscales were useful in differentiating between responders and nonresponders to TMS intervention for tinnitus. These findings are not definitive, but suggest potential factors that contribute to perceived benefit following TMS.
Overall, the main factor associated with TMS benefit was a higher tinnitus severity score for responders at baseline. The TFI subscales helped to clarify the factors that contributed to a higher severity score at baseline. Large-scale prospective research using systematic approaches is needed to identify and describe additional factors associated with tinnitus benefit following TMS.
ClinicalTrials.gov, ID: NCT01104207 . Registered on 13 April 2010.
确定与经颅磁刺激（TMS）疗效相关的特征，将有助于深入了解为何有些人在接受TMS治疗后耳鸣得到缓解，而另一些人却没有。本研究的目的是使用耳鸣功能指数（TFI）及其子量表来确定与TMS治疗反应性相关的特定因素。
患有困扰性耳鸣的个体连续10个工作日接受2000次1赫兹的TMS脉冲治疗。主要结局指标是TFI，它会产生一个总分和八个单独的子量表分数。对一项关于TMS治疗耳鸣的前瞻性、双盲、随机安慰剂对照临床试验的活性组（n = 35）的基线数据进行分析。
基线TFI总分以及八个TFI子量表中的三个，有助于区分对TMS耳鸣干预有反应者和无反应者。这些发现并不确定，但提示了TMS后产生感知疗效的潜在因素。
总体而言，与TMS疗效相关的主要因素是有反应者在基线时耳鸣严重程度得分较高。TFI子量表有助于阐明导致基线时严重程度得分较高的因素。需要采用系统方法进行大规模前瞻性研究，以识别和描述与TMS后耳鸣疗效相关的其他因素。
ClinicalTrials.gov，标识符：NCT01104207。于2010年4月13日注册。
