富含饱和脂肪或 n-6 多不饱和脂肪酸并补充长链 n-3 多不饱和脂肪酸的饮食对血浆脂蛋白谱的影响。
Effect of diets rich in either saturated fat or n-6 polyunsaturated fatty acids and supplemented with long-chain n-3 polyunsaturated fatty acids on plasma lipoprotein profiles.
机构信息
Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia.
Metabolomics Platform, Rovira i Virgili University, IISPV, Tarragona, Spain.
出版信息
Eur J Clin Nutr. 2017 Nov;71(11):1297-1302. doi: 10.1038/ejcn.2017.56. Epub 2017 May 10.
BACKGROUND/OBJECTIVES: Abnormalities in lipoprotein profiles (size, distribution and concentration) play an important role in the pathobiology of atherosclerosis and coronary artery disease. Dietary fat, among other factors, has been demonstrated to modulate lipoprotein profiles. We aimed to investigate if background dietary fat (saturated, SFA versus omega-6 polyunsaturated fatty acids, n-6PUFA) was a determinant of the effects of LCn-3PUFA supplementation on lipoprotein profiles.
SUBJECTS/METHODS: A randomized controlled clinical intervention trial in a parallel design was conducted. Healthy subjects (n=26) were supplemented with 400 mg eicosapentaenoic acid plus 2000 mg docosahexaenoic acid daily and randomized to consume diets rich in either SFA or n-6PUFA for a period of 6 weeks. Blood samples, collected at baseline and after 6 weeks of intervention, were assessed for plasma lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) determined using nuclear magnetic resonance spectroscopy.
RESULTS
Study participants receiving the SFA or the n-6PUFA enriched diets consumed similar percentage energy from fat (41 and 42% respectively, P=0.681). However, subjects on the SFA diet consumed 50% more energy as saturated fat and 77% less as linoleic acid than those consuming the n-6PUFA diet (P<0.001). The diets rich in SFA and n-6PUFA reduced the concentration of total very-low-density lipoprotein (VLDL) particles (P<0.001, both), and their subclasses and increased VLDL (P=0.042 and P=0.007, respectively) and LDL (P=0.030 and 0.027, respectively) particle size. In addition, plasma triglyceride concentration was significantly reduced by LCn-3PUFA supplementation irrespective of the dietary fat.
CONCLUSIONS
LCn-3PUFA modulated lipoprotein profiles in a similar fashion when supplemented in diets rich in either SFA or n-6PUFA.
背景/目的：脂蛋白谱（大小、分布和浓度）的异常在动脉粥样硬化和冠状动脉疾病的病理生物学中起着重要作用。膳食脂肪等因素已被证明可以调节脂蛋白谱。我们旨在研究背景膳食脂肪（饱和脂肪，SFA 与 ω-6 多不饱和脂肪酸，n-6PUFA）是否是 LCn-3PUFA 补充对脂蛋白谱影响的决定因素。
受试者/方法：进行了一项平行设计的随机对照临床干预试验。健康受试者（n=26）每天补充 400mg 二十碳五烯酸加 2000mg 二十二碳六烯酸，并随机分为两组，分别食用富含 SFA 或 n-6PUFA 的饮食 6 周。在干预 6 周后采集血样，使用核磁共振光谱法评估血浆脂蛋白谱（脂蛋白大小、浓度和亚类分布）。
结果
接受 SFA 或 n-6PUFA 富集饮食的研究参与者摄入的脂肪百分比相似（分别为 41%和 42%，P=0.681）。然而，与食用 n-6PUFA 饮食的受试者相比，食用 SFA 饮食的受试者摄入的饱和脂肪多 50%，而亚油酸少 77%（P<0.001）。富含 SFA 和 n-6PUFA 的饮食降低了总极低密度脂蛋白（VLDL）颗粒的浓度（P<0.001，两者）及其亚类，并增加了 VLDL（P=0.042 和 P=0.007，分别）和 LDL（P=0.030 和 0.027，分别）颗粒大小。此外，LCn-3PUFA 补充剂无论饮食中的脂肪如何，均可显著降低血浆甘油三酯浓度。
结论
LCn-3PUFA 在富含 SFA 或 n-6PUFA 的饮食中补充时，以相似的方式调节脂蛋白谱。
Zotero 插件