单分散硒取代羟磷灰石：可控合成与生物相容性。
Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility.
机构信息
School of Civil Engineering, Xi'an University of Architecture and Technology, Shaanxi 710055, PR China; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
出版信息
Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:596-602. doi: 10.1016/j.msec.2016.12.106. Epub 2016 Dec 24.
Hydroxyapatite (HA) is the major inorganic component of natural bone tissue. As an essential trace element, selenium involves in antioxidation and anticancer of human body. So far, ion-doped hydroxyapatites (HAs) are widely investigated owing to their great applications in field of biomaterial, biological labeling. In this paper, series of monodisperse HA doped with SeO (SeHA) was successfully synthesized based on the liquid-solid-solution (LSS) strategy. The obtained samples were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and energy-dispersive spectrometer (EDS). The results indicated that the SeO doping level of the Se/(P+Se) molar ratio of 0-0.4 can be requisitely controlled, and the morphology of SeHA nanoparticles varied from nanorods to nanoneedles with increasing Se/(P+Se) molar ratio. Significantly, the as-synthesized SeHA nanocrystals exhibit a low cytotoxicity for osteoblastic cells, showing exciting potentials for application in artificial scaffold materials inhibiting of tumor growth in bone.
羟基磷灰石（HA）是天然骨组织的主要无机成分。硒作为一种必需的微量元素，参与人体的抗氧化和抗癌作用。到目前为止，掺杂离子的羟基磷灰石（HA）由于其在生物材料、生物标记等领域的广泛应用而受到广泛研究。本文采用液-固-溶液（LSS）策略成功合成了一系列单分散硒掺杂羟基磷灰石（SeHA）。通过透射电子显微镜（TEM）、X 射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和能谱仪（EDS）对所得样品进行了表征。结果表明，可以适当控制 SeO 的掺杂水平，即 Se/（P+Se）摩尔比为 0-0.4，并且随着 Se/（P+Se）摩尔比的增加，SeHA 纳米粒子的形态从纳米棒变为纳米针。值得注意的是，所合成的 SeHA 纳米晶对成骨细胞的细胞毒性较低，在抑制骨内肿瘤生长的人工支架材料应用方面具有令人兴奋的潜力。
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