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1
One size doesn't fit all: Should we reconsider the introduction of cold-stored platelets in blood bank inventories?一刀切并不适用于所有情况：我们是否应该重新考虑在血库库存中引入冷藏血小板？
F1000Res. 2017 Feb 1;6:95. doi: 10.12688/f1000research.10363.1. eCollection 2017.
2
Cold stored platelets in the management of bleeding: is it about bioenergetics?冷存储血小板在出血管理中的应用：是否与生物能量学有关？
Platelets. 2023 Dec;34(1):2188969. doi: 10.1080/09537104.2023.2188969.
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Frozen and cold-stored platelets: reconsidered platelet products.冷冻和冷藏血小板：重新考虑血小板制品。
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4
Platelet preservation: agitation and containers.血小板保存：振荡与容器
Transfus Apher Sci. 2011 Jun;44(3):297-304. doi: 10.1016/j.transci.2011.03.005. Epub 2011 Apr 21.
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Relative hemostatic effectiveness of human platelets stored at 4 degrees and 22 degrees C.4摄氏度和22摄氏度储存的人血小板的相对止血效果
J Lab Clin Med. 1978 Apr;91(4):618-24.
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Suitability of measurement of swirling as a marker of platelet shape change in concentrates stored for transfusion.将旋转测量作为储存用于输血的浓缩物中血小板形状变化标志物的适用性。
Platelets. 2006 Sep;17(6):393-6. doi: 10.1080/09537100600757695.
7
New strategies for the optimal use of platelet transfusions.血小板输注最佳使用的新策略。
Hematology Am Soc Hematol Educ Program. 2008:198-204. doi: 10.1182/asheducation-2008.1.198.
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Temperature cycling improves in vivo recovery of cold-stored human platelets in a mouse model of transfusion.温度循环可改善冷藏人血小板在输血小鼠模型中的体内恢复。
Transfusion. 2013 Jun;53(6):1178-86. doi: 10.1111/j.1537-2995.2012.03896.x. Epub 2012 Sep 24.
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[Fluid storage of thrombocytes. In vitro viability of thrombocytes at 12 degrees C storage temperature].[血小板的液体储存。血小板在12摄氏度储存温度下的体外活力]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1985;112(5):742-51.
10
[Liquid storage of thrombocytes: in vivo survival capability of thrombocytes after storage at +12 degrees C].[血小板的液体储存：在+12℃储存后血小板的体内存活能力]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(3):373-8.

引用本文的文献

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Delayed cold-stored vs. room temperature stored platelet transfusions in bleeding adult cardiac surgery patients-a randomized multicentre pilot study (PLTS-1).出血性成人心脏手术患者中延迟冷藏与室温储存血小板输注的比较——一项随机多中心试点研究（PLTS-1）
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In vitro Hemostatic Functions of Cold-Stored Platelets.冷储存血小板的体外止血功能
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The Missing Pieces to the Cold-Stored Platelet Puzzle.冷藏血小板之谜的缺失环节。
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14-3-3ζ Regulates the Platelet Apoptosis During Storage.14-3-3ζ调节血小板储存期间的凋亡。
Indian J Hematol Blood Transfus. 2020 Apr;36(2):324-329. doi: 10.1007/s12288-019-01229-z. Epub 2019 Nov 14.
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The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine.血小板储存温度对止血、免疫和内皮功能的影响：个性化医疗的潜力。
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Hypothermia-induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model.低温诱导的脾血小板池激活作为一种小鼠模型中血栓性疾病的危险因素。
J Thromb Haemost. 2019 Oct;17(10):1762-1771. doi: 10.1111/jth.14555. Epub 2019 Jul 17.

本文引用的文献

1
Refrigerated storage of platelets initiates changes in platelet surface marker expression and localization of intracellular proteins.血小板的冷藏储存会引发血小板表面标志物表达及细胞内蛋白质定位的变化。
Transfusion. 2016 Oct;56(10):2548-2559. doi: 10.1111/trf.13723. Epub 2016 Jul 26.
2
Refrigeration and cryopreservation of platelets differentially affect platelet metabolism and function: a comparison with conventional platelet storage conditions.血小板的冷藏和冷冻保存对血小板代谢和功能有不同影响：与传统血小板储存条件的比较。
Transfusion. 2016 Jul;56(7):1807-18. doi: 10.1111/trf.13630. Epub 2016 May 9.
3
Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability.储存期间血小板线粒体的生物能量分析：4℃储存可延长血小板线粒体功能和活力。
Transfusion. 2016 Mar;56 Suppl 1:S76-84. doi: 10.1111/trf.13337.
4
The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function.血小板在22°C和4°C储存对血管内皮完整性和功能的影响。
Transfusion. 2016 Mar;56 Suppl 1:S52-64. doi: 10.1111/trf.13455.
5
Functional recovery of stored platelets after transfusion.输血后储存血小板的功能恢复。
Transfusion. 2016 May;56(5):1030-7. doi: 10.1111/trf.13544. Epub 2016 Mar 2.
6
Storage of platelets at 4°C in platelet additive solutions prevents aggregate formation and preserves platelet functional responses.血小板在血小板添加剂溶液中于4°C储存可防止聚集体形成并保留血小板功能反应。
Transfusion. 2016 Jun;56(6):1320-8. doi: 10.1111/trf.13511. Epub 2016 Feb 8.
7
ENDOTHELIUM-DERIVED INHIBITORS EFFICIENTLY ATTENUATE THE AGGREGATION AND ADHESION RESPONSES OF REFRIGERATED PLATELETS.内皮衍生抑制剂可有效减弱冷藏血小板的聚集和黏附反应。
Shock. 2016 Feb;45(2):220-7. doi: 10.1097/SHK.0000000000000493.
8
Platelet transfusion: a systematic review of the clinical evidence.血小板输注：临床证据的系统评价
Transfusion. 2015 May;55(5):1116-27; quiz 1115. doi: 10.1111/trf.12943. Epub 2014 Nov 12.
9
Bacterial contamination in platelet concentrates.血小板浓缩物中的细菌污染。
Vox Sang. 2014 Apr;106(3):256-83. doi: 10.1111/vox.12098.
10
Hemostatic function of apheresis platelets stored at 4°C and 22°C.在4°C和22°C储存的单采血小板的止血功能。
Shock. 2014 May;41 Suppl 1(0 1):54-61. doi: 10.1097/SHK.0000000000000082.

一刀切并不适用于所有情况：我们是否应该重新考虑在血库库存中引入冷藏血小板？

One size doesn't fit all: Should we reconsider the introduction of cold-stored platelets in blood bank inventories?

作者信息

Berzuini Alessandra, Spreafico Marta, Prati Daniele

机构信息

Department of Transfusion Medicine and Hematology, Azienda Socio Sanitaria Territoriale (ASST) di Lecco, Alessandro Manzoni Hospital, Lecco, Italy.

出版信息

F1000Res. 2017 Feb 1;6:95. doi: 10.12688/f1000research.10363.1. eCollection 2017.

DOI:10.12688/f1000research.10363.1
PMID:28184297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5288671/
Abstract

Platelet concentrates are universally prepared with a standard method and stored for 5 days at room temperature (20-24°C) in gentle agitation. Currently, there is a renewed interest in the possibility of storing platelet concentrates below the standard temperatures. In fact, cold platelets might be more effective in bleeding patients and have a lower risk of bacterial transmission. Inventories including platelets at different temperatures may favour patient-centred strategies for prophylactic or therapeutic transfusions.

摘要

血小板浓缩物通常采用标准方法制备，并在室温（20-24°C）下轻柔搅拌储存5天。目前，人们对在低于标准温度下储存血小板浓缩物的可能性重新产生了兴趣。事实上，低温血小板对出血患者可能更有效，且细菌传播风险更低。包含不同温度下血小板的库存可能有利于以患者为中心的预防性或治疗性输血策略。