School of Nursing & School of Public Health, Yangzhou University, Yangzhou, Jiangsu, China.
Department of Psychology, Stockholm University, Stockholm, Sweden.
Lipids Health Dis. 2023 Mar 11;22(1):38. doi: 10.1186/s12944-023-01795-2.
There is limited longitudinal evidence supporting the association between the hypertriglyceridemic-waist (HTGW) phenotype and hyperuricemia. This study aimed to examine the longitudinal relationship between hyperuricemia and the HTGW phenotype among males and females.
A total of 5562 hyperuricemia-free participants aged 45 or over from the China Health and Retirement Longitudinal Study (mean age: 59.0) were followed for 4 years. The HTGW phenotype was defined as having elevated triglyceride levels and enlarged waist circumference (cutoffs for males: 2.0 mmol/L and 90 cm; females: 1.5 mmol/L and 85 cm). Hyperuricemia was determined by uric acid cutoffs (males: 7 mg/dl; females: 6 mg/dl. Multivariate logistic regression models were used to assess the association between the HTGW phenotype and hyperuricemia. The joint effect of the HTGW phenotype and sex on hyperuricemia was quantified, and the multiplicative interaction was assessed.
During the four-year follow-up, 549 (9.9%) incident hyperuricemia cases were ascertained. Compared with those with normal levels of triglycerides and waist circumference, participants with the HTGW phenotype had the highest risk of hyperuricemia (OR: 2.67; 95% CI: 1.95 to 3.66), followed by an OR of 1.96 (95% CI: 1.40 to 2.74) for only higher triglyceride levels and 1.39 (95% CI: 1.03 to 1.86) for only greater waist circumference. The association between HTGW and hyperuricemia was more prominent among females (OR = 2.36; 95% CI: 1.77 to 3.15) than males (OR = 1.29; 95% CI: 0.82 to 2.04), with evidence of a multiplicative interaction (P = 0.006).
Middle-aged and older females with the HTGW phenotype may at the highest risk of hyperuricemia. Future hyperuricemia prevention interventions should be primarily targeted for females with the HTGW phenotype.
目前仅有少量纵向研究支持中心性肥胖伴高三酰甘油血症（HTGW）表型与高尿酸血症之间的关联。本研究旨在探讨高尿酸血症与男性和女性HTGW 表型之间的纵向关系。
本研究共纳入了 5562 例年龄在 45 岁及以上且血尿酸正常的中国健康与养老追踪调查参与者（平均年龄 59.0 岁），随访 4 年。HTGW 表型定义为三酰甘油水平升高和腰围增大（男性：2.0mmol/L 和 90cm；女性：1.5mmol/L 和 85cm）。高尿酸血症定义为血尿酸水平升高（男性：7mg/dl；女性：6mg/dl）。采用多变量 logistic 回归模型评估 HTGW 表型与高尿酸血症之间的关联。并量化 HTGW 表型和性别对高尿酸血症的联合作用，评估两者之间的相乘交互作用。
在 4 年的随访期间，共确定了 549 例（9.9%）新发高尿酸血症病例。与三酰甘油和腰围水平正常者相比，HTGW 表型者发生高尿酸血症的风险最高（OR：2.67；95%CI：1.953.66），其次是仅三酰甘油水平升高者（OR：1.96；95%CI：1.402.74），仅腰围增大者（OR：1.39；95%CI：1.031.86）。HTGW 与高尿酸血症之间的关联在女性中更为显著（OR=2.36；95%CI：1.773.15），在男性中则相对较弱（OR=1.29；95%CI：0.82~2.04），存在相乘交互作用（P=0.006）。
中年及以上女性中 HTGW 表型与高尿酸血症风险增加相关。未来高尿酸血症的预防干预措施应主要针对具有 HTGW 表型的女性。
