Zaratzian C, Gouriet F, Tissot-Dupont H, Casalta J-P, Million M, Bardin N, Grisoli D, Habib G, Raoult D
UM63, CNRS 7278, IRD 198, INSERM 1095 IHU - Méditerranée Infection, Aix-Marseille Université, 19-21 Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.
Immunology Laboratory, Centre Hospitalier Universitaire, Hôpital de la Conception, AP-HM, Aix-Marseille University, Marseille, France.
Eur J Clin Microbiol Infect Dis. 2017 Jul;36(7):1159-1162. doi: 10.1007/s10096-017-2903-1. Epub 2017 Feb 9.
Antiphospholipid antibodies (aPL) may occur alone or associated with other diseases. To evaluate aPL, tested as anticardiolipin antibodies (IgG aCL) in infective endocarditis (IE) diagnosis, we investigated their prevalence in a cohort of 651 patients with IE suspicion. aPL was significantly associated with definite IE versus IE-rejected patients. Their mean levels were significantly higher in patients with definite IE versus possible IE. When applied as Duke minor criterion, they were significantly more often positive, and at higher levels, in patients with definite IE than in patients with possible or rejected IE. aPL could be helpful in difficult cases of IE diagnosis.
抗磷脂抗体（aPL）可能单独出现，也可能与其他疾病相关。为了评估在感染性心内膜炎（IE）诊断中作为抗心磷脂抗体（IgG aCL）检测的aPL，我们调查了651例疑似IE患者队列中aPL的患病率。与IE被排除的患者相比，aPL与确诊IE显著相关。确诊IE患者的aPL平均水平显著高于可能患有IE的患者。当作为杜克次要标准应用时，确诊IE患者中aPL呈阳性的频率显著更高，且水平更高，高于可能患有IE或IE被排除的患者。aPL在IE诊断的疑难病例中可能会有帮助。
