基于适体导向细胞募集的膝关节修复多功能再生支架。
A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer-Directed Cell Recruitment.
机构信息
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
出版信息
Adv Mater. 2017 Apr;29(15). doi: 10.1002/adma.201605235. Epub 2017 Feb 10.
To solve the challenge of poor knee repair, an aptamer-bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The scaffold can efficiently recruit MSCs to the defect and induce the directional differentiation of MSCs, thus successfully achieving simultaneous regeneration of cartilage and bone in the knee joint.
为了解决膝关节修复效果不佳的难题，设计了一种适体双层支架用于招募自体间充质干细胞（MSC）并促进软骨-骨再生。该支架能够高效招募 MSC 至缺损部位，并诱导 MSC 的定向分化，从而成功实现膝关节内的软骨和骨同步再生。
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