Lehman T J, Reichlin M, Santner T J, Silverman E, Petty R E, Spencer C H, Harley J B
Department of Pediatrics, Cornell University Medical College, New York, New York.
Arthritis Rheum. 1989 Nov;32(11):1414-20. doi: 10.1002/anr.1780321110.
In this study of 71 children with systemic lupus erythematosus (SLE) and 188 of their first-degree relatives, we demonstrated that the development of SLE in male children younger than age 18, and in all children younger than age 10 at the time of diagnosis, is strongly correlated with the presence of antibodies to Ro (SS-A) in the mother's serum. When the relative antibody concentration was quantified, increased quantities of antibody to Ro (SS-A) were also found in mothers of male probands and mothers of probands whose SLE was diagnosed before age 10. No similar association was found for the presence or amount of antibody to Ro (SS-A) in other first-degree relatives or for antibody to La (SS-B) or nuclear RNP in any relative. The explanation for the association of maternal anti-Ro (SS-A) antibodies and early diagnosis of SLE or male sex is not apparent. These findings extend the association of maternal antibodies to Ro (SS-A) from transient "neonatal" SLE to SLE in childhood, and suggest that maternal antibodies to Ro (SS-A) may be of fundamental importance in the pathogenesis of some cases of childhood SLE.
在这项针对71名系统性红斑狼疮（SLE）患儿及其188名一级亲属的研究中，我们发现，18岁以下男童以及所有确诊时年龄小于10岁的儿童患SLE与母亲血清中抗Ro（SS - A）抗体的存在密切相关。当对相对抗体浓度进行定量分析时，在男性先证者的母亲以及SLE在10岁前确诊的先证者的母亲中，也发现了抗Ro（SS - A）抗体数量的增加。在其他一级亲属中，未发现抗Ro（SS - A）抗体的存在或数量与抗La（SS - B）抗体或核RNP抗体之间存在类似关联。母亲抗Ro（SS - A）抗体与SLE早期诊断或男性患病之间关联的原因尚不清楚。这些发现将母亲抗Ro（SS - A）抗体的关联从短暂的“新生儿”SLE扩展到儿童期SLE，并表明母亲抗Ro（SS - A）抗体可能在某些儿童SLE病例的发病机制中具有重要意义。
