Thabet A M, Kottapally M, Hemphill J Claude
Department of Neurology, University of California, San Francisco, CA, USA.
Department of Neurology, University of Miami, Miami, FL, USA.
Handb Clin Neurol. 2017;140:177-194. doi: 10.1016/B978-0-444-63600-3.00011-8.
Intracerebral hemorrhage (ICH) is a potentially devastating neurologic injury representing 10-15% of stroke cases in the USA each year. Numerous risk factors, including age, hypertension, male gender, coagulopathy, genetic susceptibility, and ethnic descent, have been identified. Timely identification, workup, and management of this condition remain a challenge for clinicians as numerous factors can present obstacles to achieving good functional outcomes. Several large clinical trials have been conducted over the prior decade regarding medical and surgical interventions. However, no specific treatment has shown a major impact on clinical outcome. Current management guidelines do exist based on medical evidence and consensus and these provide a framework for care. While management of hypertension and coagulopathy are generally considered basic tenets of ICH management, a variety of measures for surgical hematoma evacuation, intracranial pressure control, and intraventricular hemorrhage can be further pursued in the emergent setting for selected patients. The complexity of management in parenchymal cerebral hemorrhage remains challenging and offers many areas for further investigation. A systematic approach to the background, pathology, and early management of spontaneous parenchymal hemorrhage is provided.
脑出血(ICH)是一种潜在的毁灭性神经损伤,在美国每年占中风病例的10%-15%。已确定了许多风险因素,包括年龄、高血压、男性、凝血病、遗传易感性和种族血统。及时识别、检查和处理这种情况对临床医生来说仍然是一项挑战,因为许多因素会阻碍实现良好的功能结局。在过去十年中,已经进行了几项关于药物和手术干预的大型临床试验。然而,没有一种特定的治疗方法对临床结局产生重大影响。目前基于医学证据和共识的管理指南确实存在,这些指南提供了护理框架。虽然高血压和凝血病的管理通常被认为是脑出血管理的基本原则,但对于选定的患者,在紧急情况下可以进一步采取各种手术清除血肿、控制颅内压和治疗脑室内出血的措施。脑实质内脑出血管理的复杂性仍然具有挑战性,并且提供了许多有待进一步研究的领域。本文提供了一种针对自发性脑实质内出血的背景、病理和早期管理的系统方法。