Zou Yuanxia, Liao Lishang, Dai Jian, Mazhar Maryam, Yang Guoqiang, Wang Honglian, Dechsupa Nathupakorn, Wang Li
Research Center for Integrated Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, China.
Molecular Imaging and Therapy Research Unit, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Regen Ther. 2023 Feb 18;22:181-190. doi: 10.1016/j.reth.2023.01.006. eCollection 2023 Mar.
Intracerebral hemorrhage (ICH) is the second largest type of stroke with high mortality and morbidity. The vast majority of survivors suffer from serious neurological defects. Despite the well-established etiology and diagnose, there is still some controversy over the ideal treatment strategy. MSC-based therapy has become an attractive and promising strategy for the treatment of ICH through immune regulation and tissue regeneration. However, accumulating studies have revealed that MSC-based therapeutic effects are mainly attributed to the paracrine properties of MSC, especially small extracellular vesicles/exosome (EVs/exo) which are considered to be the key mediators of the protective efficacy from MSCs. Moreover, some papers reported that MSC-EVs/exo have better therapeutic effects than MSCs. Therefore, EVs/exo has become a new choice for the treatment of ICH stroke in recent years. In this review, we mainly concentrate on the current research progress on the use of MSC-EVs/exo in the treatment of ICH and the existing challenges in their transplation from lab to clinical practice.
脑出血（ICH）是第二大致死率和致残率都很高的中风类型。绝大多数幸存者都患有严重的神经功能缺损。尽管病因和诊断方法已经明确，但对于理想的治疗策略仍存在一些争议。基于间充质干细胞（MSC）的治疗方法通过免疫调节和组织再生，已成为治疗脑出血颇具吸引力且前景广阔的策略。然而，越来越多的研究表明，基于MSC的治疗效果主要归因于MSC的旁分泌特性，尤其是小细胞外囊泡/外泌体（EVs/exo），它们被认为是MSC发挥保护作用的关键介质。此外，一些论文报道称，MSC-EVs/exo的治疗效果优于MSC。因此，近年来EVs/exo已成为治疗脑出血性中风的新选择。在这篇综述中，我们主要关注目前使用MSC-EVs/exo治疗ICH的研究进展以及将其从实验室转化到临床实践中存在的挑战。
