Santos Jonh A M, Santos Cosme S, Almeida Claudia L A, Silva Thiago D S, Freitas Filho João R, Militão Gardenia C G, da Silva Teresinha G, da Cruz Carlos H B, Freitas Juliano C R, Menezes Paulo H
Departamento de Química, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros s/n, 52171-900, Recife, PE, Brazil; Departamento de Química, Universidade Federal de Pernambuco, Av. Jornalista Anibal Fernandes s/n, 50670-901, Recife, PE, Brazil.
Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, 50670-901, Recife, PE, Brazil.
Eur J Med Chem. 2017 Mar 10;128:192-201. doi: 10.1016/j.ejmech.2017.01.036. Epub 2017 Jan 24.
Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested tumor cells lines, being the best results observed for HL-60 cells. These compounds open new possibilities to prepare an array of more active, site-specific or selective antitumor agents. 2016 Elsevier Ltd. All rights reserved.
