American Society for Nutrition, 6100 Westchester Park Drive, College Park, MD 20740, USA.
Lipid Technologies, LLC and The Center for Spirituality and Healing, The University of Minnesota, Austin, MN 55912, USA.
Prostaglandins Leukot Essent Fatty Acids. 2018 Sep;136:15-21. doi: 10.1016/j.plefa.2017.01.012. Epub 2017 Jan 25.
Careful handling of data on fatty acid composition is needed when interpreting evidence for the influence of dietary n-3 and n-6 essential fatty acids on brain function and health conditions. The relative dietary supplies of competing n-3 and n-6 nutrients determine the balance of 20- and 22-carbon n-3 and n-6 highly unsaturated fatty acids (HUFA) which accumulate competitively at the 2-position of tissue phospholipids. In turn, the HUFA balance expressed as the %n-6 in HUFA affects the likely intensity of n-6 eicosanoid actions in diverse health conditions. As a result, measures of HUFA balance are important, valid biomarkers for designing and monitoring successful preventive nutrition interventions. Successful interventions must also consider the ability of fatty acid ligands to saturate binding sites of enzymes and receptors and give paradoxical dose-response results.
在解释膳食 n-3 和 n-6 必需脂肪酸对大脑功能和健康状况影响的证据时，需要谨慎处理脂肪酸组成的数据。竞争的 n-3 和 n-6 营养素的相对膳食供应决定了 20 碳和 22 碳 n-3 和 n-6 高度不饱和脂肪酸（HUFA）在组织磷脂 2 位的累积竞争平衡。反过来，HUFA 平衡表示为 HUFA 中的 %n-6，影响在各种健康状况下 n-6 类二十烷酸作用的可能强度。因此，HUFA 平衡的测量值是设计和监测成功的预防性营养干预措施的重要、有效的生物标志物。成功的干预措施还必须考虑脂肪酸配体饱和酶和受体结合位点的能力，并产生矛盾的剂量反应结果。
