Bibus Doug, Lands Bill
Community Faculty, University of Minnesota Center for Spirituality and Healing, and Lipid Technologies LLC, P.O. Box 216, Austin, MN 55912, United States.
Fellow, ASN, AAAS, SFRBM, 6100 Westchester Park Drive, College Park, MD 20740, United States.
Prostaglandins Leukot Essent Fatty Acids. 2015 Aug;99:19-23. doi: 10.1016/j.plefa.2015.04.005. Epub 2015 Apr 18.
People eating different balances of omega-3 and omega-6 nutrients develop predictably different proportions of competing highly unsaturated fatty acids (HUFA) in their tissue lipids. While epidemiological studies have associated wide differences in HUFA balance with disease severity, some clinical studies that did not examine wide differences failed to confirm the association. We examined the degree to which the relative amount of arachidonic acid, the major precursor of omega-6 eicosanoids, differs among people who have widely different dietary intakes of omega-3 and omega-6 nutrients. Gas chromatographic analyses of human blood samples describe the balance among n-3 and n-6 HUFA for different individuals. The proportion of the omega-6 arachidonic acid, from which potent eicosanoids are formed, is not constant. It ranges from 30% to 70% of HUFA while the competing n-3 HUFA range from 60% to 10% of HUFA. Significant differences in clinical outcomes between control and intervention groups have been seen when using dietary interventions that shift the balance of n-3 and n-6 nutrients far enough to create a biologically significant difference in the HUFA balance.
摄入不同比例ω-3和ω-6营养素的人，其体内组织脂质中竞争性高度不饱和脂肪酸（HUFA）的比例会出现可预测的差异。虽然流行病学研究将HUFA平衡的巨大差异与疾病严重程度联系起来，但一些未研究广泛差异的临床研究未能证实这种关联。我们研究了ω-6类二十烷酸的主要前体花生四烯酸的相对含量，在摄入ω-3和ω-6营养素差异很大的人群中的差异程度。对人体血液样本进行气相色谱分析，描述了不同个体中n-3和n-6 HUFA之间的平衡。能形成强效类二十烷酸的ω-6花生四烯酸的比例并不恒定。它在HUFA中占30%至70%，而与之竞争的n-3 HUFA在HUFA中占60%至10%。当使用饮食干预措施将n-3和n-6营养素的平衡改变到足以在HUFA平衡上产生生物学显著差异时，已观察到对照组和干预组在临床结果上存在显著差异。
